Platform with biomimetic electrochemical sensors for adiponectin and leptin detection in human serum.
Conductance
Impedance
Metabolic syndrome
Molecularly imprinted polymers
Polyphenol
Polyscopoletin
Journal
Talanta
ISSN: 1873-3573
Titre abrégé: Talanta
Pays: Netherlands
ID NLM: 2984816R
Informations de publication
Date de publication:
01 Apr 2020
01 Apr 2020
Historique:
received:
22
07
2019
revised:
07
12
2019
accepted:
10
12
2019
entrez:
29
1
2020
pubmed:
29
1
2020
medline:
23
9
2020
Statut:
ppublish
Résumé
Two new biomimetic sensors for the detection of adiponectin (A) and leptin (L) through molecularly imprinted polymers (MIPs) onto gold working electrodes (GWEs) were fabricated. Based on electrochemical impedance spectroscopy (EIS) results and cyclic voltammetry (CV) characteristics recorded in the development stages of the fabricated sensors, the sensors were electrochemically optimized and used in an integrated microfluidic platform to detect adiponectin/leptin via conductance signals and non-imprinted electrodes were used as references. To overcome the limitation of the low response signals after template binding non-conductive polyphenol (PP) and poliscopoletin (PS) were used for templates formation. Under optimized experimental conditions the conductance and resistance signals were obtained in the linear range of 0-50 μg ml
Identifiants
pubmed: 31987187
pii: S0039-9140(19)31276-7
doi: 10.1016/j.talanta.2019.120643
pii:
doi:
Substances chimiques
Adiponectin
0
Biocompatible Materials
0
Leptin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
120643Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.