The effect of pomegranate on oxidative stress parameters: A systematic review and meta-analysis.

Fruit and Vegetable Juices Humans Oxidative Stress Plant Extracts / administration & dosage Pomegranate Randomized Controlled Trials as Topic
Antioxidant Oxidative stress Pomegranate Randomized clinical trials

Journal

Complementary therapies in medicine
ISSN: 1873-6963
Titre abrégé: Complement Ther Med
Pays: Scotland
ID NLM: 9308777

Informations de publication

Date de publication:
Jan 2020
Historique:
received: 07 02 2019
revised: 20 11 2019
accepted: 20 11 2019
entrez: 29 1 2020
pubmed: 29 1 2020
medline: 4 9 2020
Statut: ppublish

Résumé

Pomegranate contains remarkable amounts of phenolic ingredients and it has been related to the antioxidant capacity of this fruit. Several primary studies show that pomegranate intake can improve antioxidant status. The objective of this systematic review and meta-analysis consisted in investigating the effect of pomegranate on oxidative stress (OS) parameters. A comprehensive electronic database search in Scopus, Web of science, Embase, Cochrane library and Medline was performed to identify eligible randomized controlled trials (RCTs). A meta-analysis of included studies was performed on selected variables using a random-effects model. Quality assessment was conducted by means of Cochrane risk of bias assessment tool. Systematic search yielded 575 references. A total of 11 RCTs reporting data from 484 participants included. Meta-analysis of data from 11 included RCTs did not support convincing evidence as to a significant increasing effect of pomegranate intake in TAC (SMD: 0.43 ; 95 %CI: -0.19, 1.06), Gpx (SMD: 0.18, 95 % CI: -0.25, 0.62, p = 0.4) and paraxonase (SMD: 0.36, 95 % CI: -0.50, 1.22, p= 0.41) as well as not significant decrease in Malondialdehyde (MDA) (SMD: -0.81, 95 % CI: -1.79, 0.09, P = 0.08). Future well-designed clinical trials are needed before definite conclusive claims can be made about the effect of pomegranate on OS parameters.

Identifiants

DOI: 10.1016/j.ctim.2019.102252 PMID: 31987244
pubmed: 31987244
pii: S0965-2299(19)30197-9
doi: 10.1016/j.ctim.2019.102252
pii:
doi:

Substances chimiques

Plant Extracts 0

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102252

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no conflict of interests to declare

Auteurs

Mojgan Morvaridzadeh (M)

Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: morvaridzadehm@yahoo.com.

Mahdi Sepidarkish (M)

Department of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran. Electronic address: mahdi.sepidarkish@gmail.com.

Elnaz Daneshzad (E)

Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, P. O. Box: 1416643931, Tehran, Iran. Electronic address: daneshzad@gmail.com.

Abolfazl Akbari (A)

Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: akbariia2006@gmail.com.

Gholam Reza Mobini (GR)

Cellular & Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences (SkUMS), Shahrekord, Iran. Electronic address: gmobini52@gmail.com.

Javad Heshmati (J)

Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: Javad.Heshmati@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Aliments et boissons › Boissons › Jus de fruits et de légumes › The effect of pomegranate on oxidative stress...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The effect of pomegranate on oxidative stress...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › The effect of pomegranate on oxidative stress...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › The effect of pomegranate on oxidative stress...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rosanae › Myrtales › Lythraceae › Grenadier commun › The effect of pomegranate on oxidative stress...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › The effect of pomegranate on oxidative stress...