Stereotactic Lung Irradiation in Mice Promotes Long-Term Senescence and Lung Injury.
Journal
International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Titre abrégé: Int J Radiat Oncol Biol Phys
Pays: United States
ID NLM: 7603616
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
30
07
2019
revised:
19
12
2019
accepted:
30
12
2019
pubmed:
29
1
2020
medline:
4
7
2020
entrez:
29
1
2020
Statut:
ppublish
Résumé
Lung cancer will be treated more frequently using stereotactic body radiation therapy, and preclinical research to model long-term toxicity of ablative doses of radiation is crucial. Stereotactic lung irradiation of a small volume can induce radiation pneumonitis and fibrosis in normal tissues. Senescence has been reported to contribute to lung fibrosis, and we investigated in vivo the effects of ablative doses of ionizing radiation on senescence-associated processes. The left lung of p16 Single or fractionated ablative radiation induces acute and very long-term p16 This work provides important information on the long-term effects of ablative radiation doses in the normal lung and strongly suggests that stress-induced senescence is involved in stereotactic body radiation therapy-induced late fibrosis.
Identifiants
pubmed: 31987976
pii: S0360-3016(20)30053-5
doi: 10.1016/j.ijrobp.2019.12.039
pii:
doi:
Substances chimiques
Cyclin-Dependent Kinase Inhibitor p16
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1017-1027Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.