The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components.
Animals
Cell Differentiation
/ genetics
Endoderm
/ abnormalities
Epithelium
/ embryology
Esophagus
/ abnormalities
Fluorescent Antibody Technique
Gastrointestinal Tract
/ abnormalities
Gene Expression Regulation, Developmental
Mesoderm
/ embryology
Mice
Mice, Transgenic
Organogenesis
/ genetics
SOXB1 Transcription Factors
/ deficiency
Trachea
/ abnormalities
Anterior foregut
Conditional knockout
Epithelial-mesenchymal interaction
Esophagus
Respiratory organ
SOX2
Journal
Biology open
ISSN: 2046-6390
Titre abrégé: Biol Open
Pays: England
ID NLM: 101578018
Informations de publication
Date de publication:
07 02 2020
07 02 2020
Historique:
pubmed:
29
1
2020
medline:
29
1
2020
entrez:
29
1
2020
Statut:
epublish
Résumé
In the anterior foregut (AFG) of mouse embryos, the transcription factor SOX2 is expressed in the epithelia of the esophagus and proximal branches of respiratory organs comprising the trachea and bronchi, whereas NKX2.1 is expressed only in the epithelia of respiratory organs. Previous studies using hypomorphic
Identifiants
pubmed: 31988094
pii: bio.048728
doi: 10.1242/bio.048728
pmc: PMC7044460
pii:
doi:
Substances chimiques
SOXB1 Transcription Factors
0
Sox2 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Informations de copyright
© 2020. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
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