Modified creatinine index and risk for long-term infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-Cohort Study.
Aged
Aged, 80 and over
Biomarkers
/ blood
Cardiovascular Diseases
/ blood
Cohort Studies
Creatinine
/ blood
Female
Humans
Infections
/ mortality
Longitudinal Studies
Male
Middle Aged
Proportional Hazards Models
Renal Dialysis
/ adverse effects
Renal Insufficiency, Chronic
/ complications
Risk Assessment
Risk Factors
Treatment Outcome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 01 2020
27 01 2020
Historique:
received:
27
08
2019
accepted:
13
01
2020
entrez:
29
1
2020
pubmed:
29
1
2020
medline:
16
7
2020
Statut:
epublish
Résumé
Modified creatinine (Cr) index, calculated by age, sex, pre-dialysis serum Cr concentration, and Kt/V for urea, is an indicator of skeletal muscle mass in hemodialysis (HD) patients. It remains unknown whether the modified Cr index predicts infection-related mortality in this population. We investigated the association between the modified Cr index and infection-related mortality. A total of 3046 patients registered in the Q-Cohort Study, a multicenter, observational study of HD patients, were analyzed. Associations between sex-specific quartiles (Q1-Q4) of the modified Cr index and the risk for infection-related mortality were analyzed by Cox proportional hazard model. During a median follow-up of 8.8 years, 387 patients died of infection. The estimated risk for infection-related mortality was significantly higher in the lower quartiles (Q1, Q2, and Q3) than in the highest quartile (Q4) as the reference group (hazard ratios and 95% confidence intervals [CI]: Q1, 2.89 [1.70-5.06], Q2, 2.76 [1.72-4.62], and Q3, 1.79 [1.12-2.99]). The hazard ratio (95% CI) for a 1 mg/kg/day decrease in the modified Cr index was 1.18 (1.09-1.27, P < 0.01) for infection-related mortality. In conclusion, a lower modified Cr index is associated with an increased risk for long-term infection-related mortality in the HD population.
Identifiants
pubmed: 31988325
doi: 10.1038/s41598-020-58181-6
pii: 10.1038/s41598-020-58181-6
pmc: PMC6985259
doi:
Substances chimiques
Biomarkers
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1241Références
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