Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth.

Adult Aged Animals Cell Proliferation / drug effects Colonic Neoplasms / microbiology DNA, Bacterial / genetics Fatty Acids, Volatile / metabolism Female Firmicutes / isolation & purification Gastrointestinal Microbiome / physiology Humans In Situ Hybridization, Fluorescence Intestinal Neoplasms / microbiology Intestines / microbiology Male Mice Mice, Inbred C57BL Mice, Inbred ICR Middle Aged RNA, Bacterial / genetics

Journal

Nature microbiology

ISSN: 2058-5276

Titre abrégé: Nat Microbiol

Pays: England

ID NLM: 101674869

Informations de publication

Date de publication:
03 2020

Historique:

received: 11 12 2018

accepted: 26 11 2019

pubmed: 29 1 2020

medline: 21 7 2020

entrez: 29 1 2020

Statut: ppublish

Résumé

The microbiota has been shown to promote intestinal tumourigenesis, but a possible anti-tumourigenic effect has also been postulated. Here, we demonstrate that changes in the microbiota and mucus composition are concomitant with tumourigenesis. We identified two anti-tumourigenic strains of the microbiota-Faecalibaculum rodentium and its human homologue, Holdemanella biformis-that are strongly under-represented during tumourigenesis. Reconstitution of Apc

Identifiants

DOI: 10.1038/s41564-019-0649-5 PMID: 31988379 PMC: PMC7048616

pubmed: 31988379

doi: 10.1038/s41564-019-0649-5

pii: 10.1038/s41564-019-0649-5

pmc: PMC7048616

mid: EMS85060

doi:

Substances chimiques

DNA, Bacterial 0

Fatty Acids, Volatile 0

RNA, Bacterial 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

511-524

Subventions

Organisme : European Research Council

ID : 615735

Pays : International

Commentaires et corrections

Type : CommentIn

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