Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.
MMP-13
curcumol
liver fibrosis
liver sinusoidal endothelial cell (LSEC)
uPA
uPAR
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
24
03
2019
revised:
10
12
2019
accepted:
05
01
2020
pubmed:
29
1
2020
medline:
31
7
2020
entrez:
29
1
2020
Statut:
ppublish
Résumé
Previous studies have suggested strong antifibrotic activity of curcumol in the liver; the underlying mechanisms of which, however, remain largely unknown. Aiming to investigate the role of curcumol in regulating early and advanced liver fibrosis, we designed a rat model with advanced liver fibrosis and cell model with an initial fibrotic stage. Model rats induced by CCl
Substances chimiques
Sesquiterpenes
0
curcumol
9190RTN07X
Urokinase-Type Plasminogen Activator
EC 3.4.21.73
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1421-1435Subventions
Organisme : National Natural Science Foundation of China
ID : 81460628 and 81660705
Organisme : the program from Education Department of Guangxi Zhuang Autonomous Region
ID : 2018KY0286
Organisme : the program from Science and Technology Bureau of Chengdu
ID : 2016-XT00-00033-GX
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
Références
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