Preclinical murine tumor models: a structural and functional perspective.
EMT
TGFβ
cancer biology
immunology
inflammation
microenvironment
spontaneous tumors
transplanted tumors
vascularization
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
28 Jan 2020
28 Jan 2020
Historique:
received:
02
08
2019
accepted:
06
01
2020
entrez:
29
1
2020
pubmed:
29
1
2020
medline:
2
10
2020
Statut:
epublish
Résumé
The goal of this review is to pinpoint the specific features, including the weaknesses, of various tumor models, and to discuss the reasons why treatments that are efficient in murine tumor models often do not work in clinics. In a detailed comparison of transplanted and spontaneous tumor models, we focus on structure-function relationships in the tumor microenvironment. For instance, the architecture of the vascular tree, which depends on whether tumor cells have gone through epithelial-mesenchymal transition, is determinant for the extension of the spontaneous necrosis, and for the intratumoral localization of the immune infiltrate. Another key point is the model-dependent abundance of TGFβ in the tumor, which controls the variable susceptibility of different tumor models to treatments. Grounded in a historical perspective, this review provides a rationale for checking factors that will be key for the transition between preclinical murine models and clinical applications.
Identifiants
pubmed: 31990272
doi: 10.7554/eLife.50740
pii: 50740
pmc: PMC6986875
doi:
pii:
Substances chimiques
Carcinogens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministère de l'Éducation Nationale
ID : Graduate Student Fellowship
Organisme : Worldwide Cancer Research
ID : AICR # 13-0260
Pays : United Kingdom
Organisme : Ligue Contre le Cancer
ID : RS18/75-61
Organisme : Centre National de la Recherche Scientifique
ID : Core funding
Organisme : Inserm
ID : Core funding
Organisme : Paris Descartes University
ID : Core funding
Organisme : Fonds De La Recherche Scientifique - FNRS
ID : 28095636
Informations de copyright
© 2020, Guerin et al.
Déclaration de conflit d'intérêts
MG, VF, BV, NB, AT No competing interests declared
Références
Br J Cancer. 1955 Dec;9(4):539-49
pubmed: 13304213
Science. 2014 May 23;344(6186):921-5
pubmed: 24812208
Cell Mol Life Sci. 2011 Jan;68(1):97-107
pubmed: 20820849
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
Nat Med. 2014 Nov;20(11):1301-9
pubmed: 25344738
Nature. 2013 Jul 11;499(7457):214-218
pubmed: 23770567
Science. 1999 Apr 30;284(5415):808-12
pubmed: 10221914
Cancer Res. 2016 Dec 1;76(23):6768-6773
pubmed: 27872099
J Clin Oncol. 2011 Aug 1;29(22):2965-71
pubmed: 21709202
Int J Cancer. 2017 Dec 15;141(12):2551-2561
pubmed: 28833076
Nat Med. 2016 Apr;22(4):433-8
pubmed: 26901407
Cancer Cell. 2005 May;7(5):411-23
pubmed: 15894262
Oncogene. 2000 Feb 21;19(8):1114-22
pubmed: 10713698
Radiother Oncol. 2004 Aug;72(2):221-30
pubmed: 15297140
Int J Cancer. 2001 Sep 1;93(5):693-8
pubmed: 11477580
J Immunol. 2003 Apr 15;170(8):4273-80
pubmed: 12682262
Nat Rev Cancer. 2004 Nov;4(11):839-49
pubmed: 15516957
Am J Pathol. 2007 Mar;170(3):793-804
pubmed: 17322365
Vet Pathol. 2002 Jul;39(4):445-51
pubmed: 12126147
Nat Cell Biol. 2000 Oct;2(10):737-44
pubmed: 11025665
J Clin Invest. 1998 Feb 15;101(4):890-8
pubmed: 9466984
Bacteriol Rev. 1962 Sep;26:336-53
pubmed: 13961186
Cancer Discov. 2017 Aug;7(8):818-831
pubmed: 28572459
Cancer. 1971 Mar;27(3):635-42
pubmed: 5549497
Cancer Res. 2002 Feb 1;62(3):747-55
pubmed: 11830529
Nature. 2012 Feb 08;482(7385):400-4
pubmed: 22318521
Nature. 2014 May 29;509(7502):S60-1
pubmed: 24870823
Cancer Res. 1997 Aug 15;57(16):3325-30
pubmed: 9269988
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20212-7
pubmed: 24277834
Nature. 2014 Nov 6;515(7525):134-7
pubmed: 25156255
J Exp Med. 1941 Mar 31;73(4):461-74
pubmed: 19871090
Immunity. 2019 May 21;50(5):1249-1261.e5
pubmed: 30952606
Princess Takamatsu Symp. 1991;22:339-47
pubmed: 1726933
Curr Treat Options Oncol. 2016 Aug;17(8):41
pubmed: 27315067
Oncoimmunology. 2016 Jun 21;5(8):e1191731
pubmed: 27622062
Nature. 2017 Dec 7;552(7683):116-120
pubmed: 29186113
Mol Med. 1994 Nov;1(1):71-81
pubmed: 8790603
Expert Opin Biol Ther. 2007 Nov;7(11):1705-21
pubmed: 17961093
Cell. 1996 Aug 9;86(3):353-64
pubmed: 8756718
Clin Cancer Res. 2013 Oct 15;19(20):5626-35
pubmed: 23983257
Eur J Cancer Clin Oncol. 1982 Feb;18(2):155-65
pubmed: 7201391
Nature. 2014 Sep 25;513(7519):559-63
pubmed: 25043024
Nat Commun. 2018 Jan 2;9(1):32
pubmed: 29296022
J Natl Cancer Inst. 1961 Mar;26:601-10
pubmed: 13689276
Cancer Res. 1953 Mar;13(3):276-8
pubmed: 13042818
Cancer Res. 1961 Jan;21:17-25
pubmed: 13712361
Cancer Discov. 2017 Nov;7(11):1320-1335
pubmed: 28790030
Cancer Discov. 2018 Apr;8(4):395-402
pubmed: 29545369
J Immunol. 2013 Mar 1;190(5):2464-71
pubmed: 23359505
Recent Results Cancer Res. 2008;177:137-50
pubmed: 18084956
Nat Rev Cancer. 2003 Jun;3(6):453-8
pubmed: 12778135
Semin Oncol. 2002 Dec;29(6 Suppl 16):15-8
pubmed: 12516034
Nature. 1969 Apr 5;222(5188):33-6
pubmed: 5775827
Nature. 2012 Feb 08;482(7385):405-9
pubmed: 22318517
Trends Immunol. 2015 Apr;36(4):198-216
pubmed: 25857662
Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19402-7
pubmed: 24218566
Cell. 2016 Mar 24;165(1):35-44
pubmed: 26997480
Bioessays. 2012 Feb;34(2):149-57
pubmed: 22102361
Nat Rev Immunol. 2017 Feb;17(2):97-111
pubmed: 27748397
Genome Med. 2017 Apr 19;9(1):34
pubmed: 28420421
Mol Cancer Ther. 2003 Jul;2(7):611-6
pubmed: 12883033
Clin Cancer Res. 2007 Apr 1;13(7):2168-77
pubmed: 17404101
J Cancer Res Clin Oncol. 1979 Oct;95(2):187-96
pubmed: 521452
Nat Rev Drug Discov. 2006 Sep;5(9):741-54
pubmed: 16915232
Nature. 2014 Nov 27;515(7528):568-71
pubmed: 25428505
Br J Cancer. 1968 Jun;22(2):258-73
pubmed: 5660132
BMC Cancer. 2015 Mar 10;15:112
pubmed: 25884767
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Cancer Cell. 2003 Oct;4(4):291-9
pubmed: 14585356
Cancer Immunol Res. 2014 Feb;2(2):142-53
pubmed: 24778278
Genome Med. 2017 Feb 24;9(1):16
pubmed: 28231819
Immunity. 2009 Jul 17;31(1):131-44
pubmed: 19604492
Oncoimmunology. 2013 Dec 1;2(12):e26968
pubmed: 24498562
Curr Stem Cell Res Ther. 2012 May;7(3):217-28
pubmed: 22329580
Br J Cancer. 2004 Feb 9;90(3):657-64
pubmed: 14760381
J Exp Med. 1914 Nov 1;20(5):433-51
pubmed: 19867833
Adv Exp Med Biol. 2005;566:59-65
pubmed: 16594135
Am J Pathol. 1982 Dec;109(3):259-69
pubmed: 6758603
J Cancer. 2015 Jul 15;6(9):843-8
pubmed: 26284135
Nat Rev Cancer. 2007 Sep;7(9):645-58
pubmed: 17687385
Mutat Res Rev Mutat Res. 2017 Oct;774:12-24
pubmed: 29173495
Am J Pathol. 2003 Jan;162(1):183-93
pubmed: 12507901
Nat Med. 2012 Mar 06;18(3):344-6; author reply 346
pubmed: 22395693
J Immunol. 2007 Feb 1;178(3):1357-62
pubmed: 17237382
Cell. 2015 Sep 24;163(1):39-53
pubmed: 26406370
Cancer Cell. 2012 Mar 20;21(3):418-29
pubmed: 22439937
Immunity. 2001 Jun;14(6):715-25
pubmed: 11420042
Science. 2016 Mar 25;351(6280):1463-9
pubmed: 26940869
Cancer Cell. 2007 Feb;11(2):147-60
pubmed: 17292826
Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9609-14
pubmed: 10931950
Clin Cancer Res. 2005 Feb 1;11(3):971-81
pubmed: 15709162
J Immunol. 2013 May 15;190(10):5216-25
pubmed: 23585680
J Immunol. 2012 May 15;188(10):4866-75
pubmed: 22504644
J Exp Med. 2006 Jul 10;203(7):1651-6
pubmed: 16801397
Cancer Res. 2014 Jan 15;74(2):436-45
pubmed: 24302580
Cancer Res. 2009 Sep 15;69(18):7366-74
pubmed: 19738062
J Immunol. 2007 May 1;178(9):5552-62
pubmed: 17442937
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3916-20
pubmed: 8171012
Science. 2010 Nov 5;330(6005):827-30
pubmed: 21051638
J Natl Cancer Inst. 1962 Aug;29:389-94
pubmed: 13877297
Crit Rev Oncog. 1999;10(4):303-60
pubmed: 10654929
Nat Med. 2011 Mar;17(3):320-9
pubmed: 21383745
Ann Oncol. 2019 Jan 1;30(1):44-56
pubmed: 30395155
N Engl J Med. 1971 Nov 18;285(21):1182-6
pubmed: 4938153
Cancer Res. 1961 Oct;21:1281-300
pubmed: 14481701
Clin Transl Immunology. 2014 Aug 01;3(8):e22
pubmed: 25505970
Oncoimmunology. 2017 Jul 7;6(10):e1346765
pubmed: 29123960
Blood. 2001 Jan 15;97(2):339-45
pubmed: 11154206
Oncotarget. 2015 Sep 29;6(29):27832-46
pubmed: 26337837
Cell. 2018 Sep 6;174(6):1373-1387.e19
pubmed: 30193111
J Exp Med. 2005 Mar 7;201(5):737-46
pubmed: 15753207
Cell. 2002 Jan 25;108(2):135-44
pubmed: 11832204
J Exp Med. 2005 Dec 19;202(12):1691-701
pubmed: 16365148
Science. 2015 Apr 3;348(6230):69-74
pubmed: 25838375
Nat Med. 1995 Aug;1(8):792-7
pubmed: 7585182
Gastroenterology. 2015 Jul;149(1):201-10
pubmed: 25888329
Immunity. 2018 Mar 20;48(3):399-416
pubmed: 29562192
Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2550-5
pubmed: 18268354
Mol Aspects Med. 2011 Apr;32(2):71-87
pubmed: 21540050
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
Biochem Soc Trans. 2019 Aug 30;47(4):961-972
pubmed: 31341034
AMA Arch Pathol. 1958 Oct;66(4):550-68
pubmed: 13582395
Pigment Cell Res. 1992 Nov;5(5 Pt 2):344-7
pubmed: 1292018
Cancer Discov. 2012 Mar;2(3):227-35
pubmed: 22448344
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4966-71
pubmed: 15051869
Nat Commun. 2019 Sep 11;10(1):4131
pubmed: 31511510
Nat Commun. 2017 Nov 10;8(1):1404
pubmed: 29123081
N Engl J Med. 2015 Jun 25;372(26):2521-32
pubmed: 25891173
Genes Dev. 1999 Oct 15;13(20):2670-7
pubmed: 10541553
Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2934-2939
pubmed: 28246332
Cancer Res. 2010 Jan 1;70(1):78-88
pubmed: 20028872
BMC Cancer. 2012 Jan 24;12:35
pubmed: 22273460
Cancer Res. 2006 Mar 15;66(6):3278-86
pubmed: 16540681
EMBO Mol Med. 2017 Feb;9(2):137-153
pubmed: 28028012
Cancer Discov. 2018 Nov;8(11):1358-1365
pubmed: 30309862
Cancer Res. 1994 Nov 15;54(22):5831-6
pubmed: 7954410
Biomed Pharmacother. 2018 Dec;108:1135-1140
pubmed: 30372814
Cancer Immunol Res. 2017 Feb;5(2):106-117
pubmed: 28073774
Cancer Res. 2000 Jul 1;60(13):3569-76
pubmed: 10910070
Mol Ther. 2014 Jan;22(1):18-27
pubmed: 24048441
Quant Imaging Med Surg. 2015 Oct;5(5):708-29
pubmed: 26682141
Cancer. 1965 Aug;18:985-94
pubmed: 14326497
Eur J Immunol. 2016 Mar;46(3):609-18
pubmed: 26626316
Science. 2015 Apr 3;348(6230):56-61
pubmed: 25838373
Nature. 2005 Sep 1;437(7055):141-6
pubmed: 16136144
Cancer Res. 1970 Oct;30(10):2470-6
pubmed: 4097429
Nat Med. 2018 Oct;24(10):1545-1549
pubmed: 30127394
Immunol Lett. 2002 Jun 3;82(1-2):85-91
pubmed: 12008039
Immunol Rev. 2007 Dec;220:102-12
pubmed: 17979842