Continuous Flow-Enabled Synthesis of Bench-Stable Bicyclo[1.1.1]pentane Trifluoroborate Salts and Their Utilization in Metallaphotoredox Cross-Couplings.


Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
21 02 2020
Historique:
pubmed: 29 1 2020
medline: 29 1 2020
entrez: 29 1 2020
Statut: ppublish

Résumé

Bicyclo[1.1.1]pentane motifs have gained increasing popularity in medicinal chemistry as bioisosteres because of their ability to impact key physicochemical properties. However, reports of direct C(sp

Identifiants

pubmed: 31990565
doi: 10.1021/acs.orglett.0c00242
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1648-1654

Auteurs

Michael D VanHeyst (MD)

Discovery Chemistry , Merck & Co., Inc. , West Point , Pennsylvania 19486 , United States.

Ji Qi (J)

Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
Process Research and Development , MSD R&D (China) Co., Ltd. , Building 21 Rongda Road , Wangjing R&D Base, Zhongguancun Electronic Zone West Zone, Beijing 100012 , China.

Anthony J Roecker (AJ)

Discovery Chemistry , Merck & Co., Inc. , West Point , Pennsylvania 19486 , United States.

Jonathan M E Hughes (JME)

Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.

Lili Cheng (L)

Chemistry Service Unit , WuXi AppTec (Tianjin) , 168 Nanhai Road , Tianjin Economic-Technological Development Area (TEDA), Tianjin 300457 , China.

Zheyu Zhao (Z)

Chemistry Service Unit , WuXi AppTec (Tianjin) , 168 Nanhai Road , Tianjin Economic-Technological Development Area (TEDA), Tianjin 300457 , China.

Jingjun Yin (J)

Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.

Classifications MeSH