Intravesical Antibiotic Administration in the Treatment of Recurrent Urinary Tract Infections: Promising Results From a Case Series.
Administration, Intravesical
Anti-Bacterial Agents
/ administration & dosage
Bacterial Load
/ drug effects
Drug Resistance, Bacterial
Female
Gentamicins
/ administration & dosage
Humans
Middle Aged
Postmenopause
Retrospective Studies
Secondary Prevention
/ methods
Tobramycin
/ administration & dosage
Treatment Outcome
Urinary Bladder
/ microbiology
Urinary Tract Infections
/ drug therapy
Journal
Female pelvic medicine & reconstructive surgery
ISSN: 2154-4212
Titre abrégé: Female Pelvic Med Reconstr Surg
Pays: United States
ID NLM: 101528690
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
entrez:
29
1
2020
pubmed:
29
1
2020
medline:
20
11
2020
Statut:
ppublish
Résumé
Intravesical antibiotic administration for the treatment of recurrent urinary tract infections (UTIs) provides targeted therapy that may be a useful alternative to oral antibiotics. The objective of the study was to assess the rate of UTIs before and after intravesical antibiotic instillations in community-dwelling postmenopausal women with recurrent UTIs. Patients with recurrent UTI who underwent antibiotic bladder instillations were included. Instillation was performed in the office by trained nursing staff using either gentamycin or tobramycin. Every instillation was preceded by bladder irrigation with sterile water. Retrospective chart review was performed to compare rates of UTIs for 6 months before and after intervention. Descriptive and nonparametric statistics were used for data analysis. Twelve patients were evaluated. The average rate of UTIs decreased from a median of 2.5 to 1.5 infections (P = 0.025) after intravesical instillations. The number of pathogen types decreased from a median of 2.5 to 1.5 after therapy (P = 0.025). There was a reduction in bacterial antibiotic resistance after completion of instillations, with an estimated median difference of -5.250 (P = 0.065). There were no adverse effects reported during instillations. Intravesical instillations offer a promising therapy for the treatment of recurrent UTIs in postmenopausal women who failed oral antibiotic therapy. Future prospective studies are needed to further elucidate the clinical utility and long-term benefits of antibiotic instillations.
Identifiants
pubmed: 31990805
doi: 10.1097/SPV.0000000000000810
pii: 01436319-202002000-00014
doi:
Substances chimiques
Anti-Bacterial Agents
0
Gentamicins
0
Tobramycin
VZ8RRZ51VK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
152-154Commentaires et corrections
Type : CommentIn
Références
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