All-source and source-specific air pollution and 10-year diabetes Incidence: Total effect and mediation analyses in the Heinz Nixdorf recall study.
Ambient air pollution
Incident diabetes
Inflammation
Mediation
Particulate matter
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
03
05
2019
revised:
12
01
2020
accepted:
13
01
2020
pubmed:
29
1
2020
medline:
12
9
2020
entrez:
29
1
2020
Statut:
ppublish
Résumé
An increasing number of studies have been published recently on the association between ambient air pollution (AP) and incident diabetes mellitus (DM), but studies investigating source-specific AP toxicity and potential mediating pathways are rare. We investigated the associations of all-source, traffic-specific, and industry-specific outdoor AP exposure with 10-year incidence of DM and potential mediation via inflammation-associated biomarkers. Data from participants of the prospective Heinz Nixdorf Recall cohort study who attended the baseline (t Of the 4,814 participants at t Our study shows that long-term exposure to total and source-specific ambient AP may increase DM risk, with consistent results observed across traffic-specific exposures. Decreases in adiponectin may play a potential role along the causal pathway.
Sections du résumé
BACKGROUND
An increasing number of studies have been published recently on the association between ambient air pollution (AP) and incident diabetes mellitus (DM), but studies investigating source-specific AP toxicity and potential mediating pathways are rare. We investigated the associations of all-source, traffic-specific, and industry-specific outdoor AP exposure with 10-year incidence of DM and potential mediation via inflammation-associated biomarkers.
METHODS
Data from participants of the prospective Heinz Nixdorf Recall cohort study who attended the baseline (t
RESULTS
Of the 4,814 participants at t
CONCLUSION
Our study shows that long-term exposure to total and source-specific ambient AP may increase DM risk, with consistent results observed across traffic-specific exposures. Decreases in adiponectin may play a potential role along the causal pathway.
Identifiants
pubmed: 31991234
pii: S0160-4120(19)31458-8
doi: 10.1016/j.envint.2020.105493
pii:
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105493Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.