Novel Genetic Variants of
cutaneous melanoma
expression quantitative trait loci
glycosylation
single-nucleotide polymorphism
survival analysis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Jan 2020
24 Jan 2020
Historique:
received:
22
12
2019
revised:
21
01
2020
accepted:
22
01
2020
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
30
1
2020
Statut:
epublish
Résumé
Because aberrant glycosylation is known to play a role in the progression of melanoma, we hypothesize that genetic variants of glycosylation pathway genes are associated with the survival of cutaneous melanoma (CM) patients. To test this hypothesis, we used a Cox proportional hazards regression model in a single-locus analysis to evaluate associations between 34,096 genetic variants of 227 glycosylation pathway genes and CM disease-specific survival (CMSS) using genotyping data from two previously published genome-wide association studies. The discovery dataset included 858 CM patients with 95 deaths from The University of Texas MD Anderson Cancer Center, and the replication dataset included 409 CM patients with 48 deaths from Harvard University nurse/physician cohorts. In the multivariable Cox regression analysis, we found that two novel single-nucleotide polymorphisms (SNPs) (
Identifiants
pubmed: 31991610
pii: cancers12020288
doi: 10.3390/cancers12020288
pmc: PMC7072252
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Institutes of Health/National Cancer Institute
ID : R01 CA100264, 2P50CA093459 and R01CA133996
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : the National Natural Science Foundation of China
ID : 81573072
Organisme : Duke Cancer Institute as part of the P30 Cancer Centre Support Grant
ID : NIH CA014236
Organisme : National Institutes of Health/National Cancer Institute
ID : R01 CA49449, P01 CA87969, UM1 CA186107 and UM1 CA167552
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