Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer.
Aged
Aged, 80 and over
CD3 Complex
/ metabolism
Carcinoembryonic Antigen
/ metabolism
Cell Line, Tumor
Cell Movement
/ immunology
Cell Survival
/ immunology
Chemokine CXCL1
/ genetics
Chemokine CXCL2
/ genetics
Databases, Genetic
Female
Gene Silencing
Humans
Immunohistochemistry
Interleukin-8
/ genetics
Kaplan-Meier Estimate
Male
Middle Aged
Muscle Neoplasms
/ genetics
Neutrophils
/ cytology
Retrospective Studies
STAT3 Transcription Factor
/ genetics
T-Lymphocytes
/ immunology
Urinary Bladder Neoplasms
/ genetics
CD3
CD66b
basal
bladder cancer
tumor-associated neutrophils
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
25 01 2020
25 01 2020
Historique:
received:
15
11
2019
revised:
16
01
2020
accepted:
23
01
2020
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
27
10
2020
Statut:
epublish
Résumé
Urothelial bladder cancers (UBCs) are distinct in two main molecular subtypes, namely basal and luminal type. Subtypes are also diverse in term of immune contexture, providing a rationale for patient selection to immunotherapy. By digital microscopy analysis of a muscle-invasive BC (MIBC) cohort, we explored the density and clinical significance of CD66b Basal type BC contained a significantly higher density of CD66b TAN are recruited in basal type MIBC by pro-inflammatory CKs. This finding establishes a groundwork for a better understanding of the UBC immunity and its relevance.
Sections du résumé
BACKGROUND
Urothelial bladder cancers (UBCs) are distinct in two main molecular subtypes, namely basal and luminal type. Subtypes are also diverse in term of immune contexture, providing a rationale for patient selection to immunotherapy.
METHODS
By digital microscopy analysis of a muscle-invasive BC (MIBC) cohort, we explored the density and clinical significance of CD66b
RESULTS
Basal type BC contained a significantly higher density of CD66b
CONCLUSIONS
TAN are recruited in basal type MIBC by pro-inflammatory CKs. This finding establishes a groundwork for a better understanding of the UBC immunity and its relevance.
Identifiants
pubmed: 31991796
pii: cells9020291
doi: 10.3390/cells9020291
pmc: PMC7072276
pii:
doi:
Substances chimiques
CD3 Complex
0
CEACAM3 protein, human
0
CXCL1 protein, human
0
CXCL2 protein, human
0
Carcinoembryonic Antigen
0
Chemokine CXCL1
0
Chemokine CXCL2
0
Interleukin-8
0
STAT3 Transcription Factor
0
STAT3 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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