Substituted Piperazines as Novel Potential Radioprotective Agents.
Cell Line, Tumor
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Humans
Maximum Tolerated Dose
Models, Molecular
Molecular Conformation
Molecular Structure
Piperazines
/ administration & dosage
Radiation, Ionizing
Radiation-Protective Agents
/ administration & dosage
Structure-Activity Relationship
Survival Analysis
cytotoxicity
maximum tolerated dose
piperazine
radiation-protective agents
synthesis de novo
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Jan 2020
25 Jan 2020
Historique:
received:
03
12
2019
revised:
14
01
2020
accepted:
20
01
2020
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
12
11
2020
Statut:
epublish
Résumé
The increasing risk of radiation exposure underlines the need for novel radioprotective agents. Hence, a series of novel 1-(2-hydroxyethyl)piperazine derivatives were designed and synthesized. Some of the compounds protected human cells against radiation-induced apoptosis and exhibited low cytotoxicity. Compared to the previous series of piperazine derivatives, compound
Identifiants
pubmed: 31991816
pii: molecules25030532
doi: 10.3390/molecules25030532
pmc: PMC7038073
pii:
doi:
Substances chimiques
Piperazines
0
Radiation-Protective Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grantová Agentura České Republiky
ID : 17-13541S
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