Mouse models of hemostasis.


Journal

Platelets
ISSN: 1369-1635
Titre abrégé: Platelets
Pays: England
ID NLM: 9208117

Informations de publication

Date de publication:
18 May 2020
Historique:
pubmed: 30 1 2020
medline: 26 11 2020
entrez: 30 1 2020
Statut: ppublish

Résumé

Hemostasis is the normal process that produces a blood clot at a site of vascular injury. Mice are widely used to study hemostasis and abnormalities of blood coagulation because their hemostatic system is similar in most respects to that of humans, and their genomes can be easily manipulated to create models of inherited human coagulation disorders. Two of the most widely used techniques for assessing hemostasis in mice are the tail bleeding time (TBT) and saphenous vein bleeding (SVB) models. Here we discuss the use of these methods in the evaluation of hemostasis, and the advantages and limits of using mice as surrogates for studying hemostasis in humans.

Identifiants

pubmed: 31992118
doi: 10.1080/09537104.2020.1719056
pmc: PMC7244364
mid: NIHMS1556402
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

417-422

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL144113
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140025
Pays : United States

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Auteurs

Bassem M Mohammed (BM)

Department of Pathology, Microbiology and Immunology, Vanderbilt University , Nashville, TN, USA.
Department of Pathology and Immunology, Washington University , St. Louis, MO, USA.

Dougald M Monroe (DM)

UNC Blood Research Center and Hematology/Oncology, University of North Carolina , Chapel Hill, NC, USA.

David Gailani (D)

Department of Pathology, Microbiology and Immunology, Vanderbilt University , Nashville, TN, USA.

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Classifications MeSH