Priming chromatin for segregation: functional roles of mitotic histone modifications.
Acetylation
Binding Sites
Centromere
/ metabolism
Chromatin
/ metabolism
Chromosome Segregation
/ physiology
Histone Code
/ physiology
Histones
/ metabolism
Humans
Methylation
Mitosis
/ physiology
Nucleosomes
/ metabolism
Phosphorylation
/ physiology
Protein Processing, Post-Translational
/ physiology
Spindle Apparatus
/ metabolism
Mitosis
chromosomal stability
chromosome condensation
chromosome segregation
histone modifications
phosphorylation
Journal
Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Titre abrégé: Cell Cycle
Pays: United States
ID NLM: 101137841
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
pubmed:
30
1
2020
medline:
15
12
2021
entrez:
30
1
2020
Statut:
ppublish
Résumé
Posttranslational modifications (PTMs) of histone proteins are important for various cellular processes including regulation of gene expression and chromatin structure, DNA damage response and chromosome segregation. Here we comprehensively review mitotic histone PTMs, in particular phosphorylations, and discuss their interplay and functions in the control of dynamic protein-protein interactions as well as their contribution to centromere and chromosome structure and function during cell division. Histone phosphorylations can create binding sites for mitotic regulators such as the chromosomal passenger complex, which is required for correction of erroneous spindle attachments and chromosome bi-orientation. Other histone PTMs can alter the structural properties of nucleosomes and the accessibility of chromatin. Epigenetic marks such as lysine methylations are maintained during mitosis and may also be important for mitotic transcription as well as bookmarking of transcriptional states to ensure the transmission of gene expression programs through cell division. Additionally, histone phosphorylation can dissociate readers of methylated histones without losing epigenetic information. Through all of these processes, mitotic histone PTMs play a functional role in priming the chromatin for faithful chromosome segregation and preventing genetic instability, one of the characteristic hallmarks of cancer cells.
Identifiants
pubmed: 31992120
doi: 10.1080/15384101.2020.1719585
pmc: PMC7145338
doi:
Substances chimiques
Chromatin
0
Histones
0
Nucleosomes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
625-641Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
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