Hospital-acquired influenza infections detected by a surveillance system over six seasons, from 2010/2011 to 2015/2016.
Adolescent
Adult
Aged
Cross Infection
/ drug therapy
Female
Hospitalization
/ statistics & numerical data
Humans
Immunologic Deficiency Syndromes
/ epidemiology
Infection Control
Influenza, Human
/ drug therapy
Length of Stay
/ statistics & numerical data
Male
Middle Aged
Seasons
Spain
/ epidemiology
Young Adult
Healthcare-associated infection
Hospitalized patients
Influenza
Nosocomial infection
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
28 Jan 2020
28 Jan 2020
Historique:
received:
18
11
2018
accepted:
14
01
2020
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
26
3
2020
Statut:
epublish
Résumé
In addition to outbreaks of nosocomial influenza, sporadic nosocomial influenza infections also occur but are generally not reported in the literature. This study aimed to determine the epidemiologic characteristics of cases of nosocomial influenza compared with the remaining severe cases of severe influenza in acute hospitals in Catalonia (Spain) which were identified by surveillance. An observational case-case epidemiological study was carried out in patients aged ≥18 years from Catalan 12 hospitals between 2010 and 2016. For each laboratory-confirmed influenza case (nosocomial or not) we collected demographic, virological and clinical characteristics. We defined patients with nosocomial influenza as those admitted to a hospital for a reason other than acute respiratory infection in whom ILI symptoms developed ≥48 h after admission and influenza virus infection was confirmed using RT-PCR. Mixed-effects regression was used to estimate the crude and adjusted OR. One thousand seven hundred twenty-two hospitalized patients with severe laboratory-confirmed influenza virus infection were included: 96 (5.6%) were classified as nosocomial influenza and more frequently had > 14 days of hospital stay (42.7% vs. 27.7%, P < .001) and higher mortality (18.8% vs. 12.6%, P < .02). The variables associated with nosocomial influenza cases in acute-care hospital settings were chronic renal disease (aOR 2.44 95% CI 1.44-4.15) and immunodeficiency (aOR 1.79 95% CI 1.04-3.06). Nosocomial infections are a recurring problem associated with high rates of chronic diseases and death. These findings underline the need for adherence to infection control guidelines.
Sections du résumé
BACKGROUND
BACKGROUND
In addition to outbreaks of nosocomial influenza, sporadic nosocomial influenza infections also occur but are generally not reported in the literature. This study aimed to determine the epidemiologic characteristics of cases of nosocomial influenza compared with the remaining severe cases of severe influenza in acute hospitals in Catalonia (Spain) which were identified by surveillance.
METHODS
METHODS
An observational case-case epidemiological study was carried out in patients aged ≥18 years from Catalan 12 hospitals between 2010 and 2016. For each laboratory-confirmed influenza case (nosocomial or not) we collected demographic, virological and clinical characteristics. We defined patients with nosocomial influenza as those admitted to a hospital for a reason other than acute respiratory infection in whom ILI symptoms developed ≥48 h after admission and influenza virus infection was confirmed using RT-PCR. Mixed-effects regression was used to estimate the crude and adjusted OR.
RESULTS
RESULTS
One thousand seven hundred twenty-two hospitalized patients with severe laboratory-confirmed influenza virus infection were included: 96 (5.6%) were classified as nosocomial influenza and more frequently had > 14 days of hospital stay (42.7% vs. 27.7%, P < .001) and higher mortality (18.8% vs. 12.6%, P < .02). The variables associated with nosocomial influenza cases in acute-care hospital settings were chronic renal disease (aOR 2.44 95% CI 1.44-4.15) and immunodeficiency (aOR 1.79 95% CI 1.04-3.06).
CONCLUSIONS
CONCLUSIONS
Nosocomial infections are a recurring problem associated with high rates of chronic diseases and death. These findings underline the need for adherence to infection control guidelines.
Identifiants
pubmed: 31992207
doi: 10.1186/s12879-020-4792-7
pii: 10.1186/s12879-020-4792-7
pmc: PMC6988218
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
80Subventions
Organisme : Instituto de Salud Carlos III (ES)
ID : Program of Surveillance, Prevention and Control of Transmissible Diseases (PREVICET) of CIBER de Epidemiología y Salud Pública (CIBERESP)
Organisme : Catalan Agency for the Management of Grants for University Research
ID : 2017/SGR 1342
Investigateurs
M Alsedà
(M)
J Álvarez
(J)
C Arias
(C)
P J Balañà
(PJ)
I Barrabeig
(I)
N Camps
(N)
M Carol
(M)
J Ferràs
(J)
G Ferrús
(G)
N Follia
(N)
P Godoy
(P)
P Bach
(P)
M Jané
(M)
A Martínez
(A)
S Minguell
(S)
I Parrón
(I)
E Plasència
(E)
M R Sala-Farré
(MR)
N Torner
(N)
R Torra
(R)
J Torres
(J)
J A Caylà
(JA)
P Gorrindo
(P)
C Rius
(C)
M A Marcos
(MA)
M D M Mosquera
(MDM)
A Vilella
(A)
A Antón
(A)
T Pumarola
(T)
M Campins
(M)
D García
(D)
E Espejo
(E)
N Freixas
(N)
M Riera Garcia
(M)
E Maraver
(E)
D Mas
(D)
R Perez
(R)
J Rebull
(J)
J Pou
(J)
G García-Pardo
(G)
M Olona
(M)
F Barcenilla
(F)
D Castellana
(D)
G Navarro-Rubio
(G)
L L Force
(LL)
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