Phage Resistance in Multidrug-Resistant Klebsiella pneumoniae ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption.
Anti-Bacterial Agents
/ pharmacology
Bacteriophages
/ physiology
Drug Resistance, Multiple, Bacterial
Evolution, Molecular
Genetic Complementation Test
Host-Pathogen Interactions
/ genetics
Humans
Klebsiella pneumoniae
/ drug effects
Microbial Sensitivity Tests
Mutation
Porins
/ genetics
Virus Attachment
bacteriophage cocktails
bacteriophage resistance
bacteriophage therapy
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
28 01 2020
28 01 2020
Historique:
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
9
6
2020
Statut:
epublish
Résumé
The evolution of phage resistance poses an inevitable threat to the efficacy of phage therapy. The strategic selection of phage combinations that impose high genetic barriers to resistance and/or high compensatory fitness costs may mitigate this threat. However, for such a strategy to be effective, the evolution of phage resistance must be sufficiently constrained to be consistent. In this study, we isolated lytic phages capable of infecting a modified
Identifiants
pubmed: 31992617
pii: mBio.02530-19
doi: 10.1128/mBio.02530-19
pmc: PMC6989104
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
OmpC protein
0
Porins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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