Conservative and disruptive modes of adolescent change in human brain functional connectivity.
Allen Human Brain Atlas
MRI
connectome
head movement
neurodevelopment
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
11 02 2020
11 02 2020
Historique:
pubmed:
30
1
2020
medline:
12
5
2020
entrez:
30
1
2020
Statut:
ppublish
Résumé
Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change in functional connectivity (FC) of resting-state oscillations between pairs of 330 cortical regions and 16 subcortical regions in 298 healthy adolescents scanned 520 times. Participants were aged 14 to 26 y and were scanned on 1 to 3 occasions at least 6 mo apart. We found 2 distinct modes of age-related change in FC: "conservative" and "disruptive." Conservative development was characteristic of primary cortex, which was strongly connected at 14 y and became even more connected in the period from 14 to 26 y. Disruptive development was characteristic of association cortex and subcortical regions, where connectivity was remodeled: connections that were weak at 14 y became stronger during adolescence, and connections that were strong at 14 y became weaker. These modes of development were quantified using the maturational index (MI), estimated as Spearman's correlation between edgewise baseline FC (at 14 y, [Formula: see text]) and adolescent change in FC ([Formula: see text]), at each region. Disruptive systems (with negative MI) were activated by social cognition and autobiographical memory tasks in prior fMRI data and significantly colocated with prior maps of aerobic glycolysis (AG), AG-related gene expression, postnatal cortical surface expansion, and adolescent shrinkage of cortical thickness. The presence of these 2 modes of development was robust to numerous sensitivity analyses. We conclude that human brain organization is disrupted during adolescence by remodeling of FC between association cortical and subcortical areas.
Identifiants
pubmed: 31992644
pii: 1906144117
doi: 10.1073/pnas.1906144117
pmc: PMC7022153
doi:
Banques de données
figshare
['10.6084/m9.figshare.11551602']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3248-3253Subventions
Organisme : Medical Research Council
ID : MC_G0802534
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K020706/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095844/Z/11/Z
Pays : United Kingdom
Organisme : Department of Health
ID : NF-SI-0514-10157
Pays : United Kingdom
Investigateurs
Edward Bullmore
(E)
Raymond Dolan
(R)
Ian Goodyer
(I)
Peter Fonagy
(P)
Peter Jones
(P)
Michael Moutoussis
(M)
Tobias Hauser
(T)
Sharon Neufeld
(S)
Rafael Romero-Garcia
(R)
Michelle St Clair
(M)
Petra Vértes
(P)
Kirstie Whitaker
(K)
Becky Inkster
(B)
Gita Prabhu
(G)
Cinly Ooi
(C)
Umar Toseeb
(U)
Barry Widmer
(B)
Junaid Bhatti
(J)
Laura Villis
(L)
Ayesha Alrumaithi
(A)
Sarah Birt
(S)
Aislinn Bowler
(A)
Kalia Cleridou
(K)
Hina Dadabhoy
(H)
Emma Davies
(E)
Ashlyn Firkins
(A)
Sian Granville
(S)
Elizabeth Harding
(E)
Alexandra Hopkins
(A)
Daniel Isaacs
(D)
Janchai King
(J)
Danae Kokorikou
(D)
Christina Maurice
(C)
Cleo McIntosh
(C)
Jessica Memarzia
(J)
Harriet Mills
(H)
Ciara O'Donnell
(C)
Sara Pantaleone
(S)
Jenny Scott
(J)
Pasco Fearon
(P)
John Suckling
(J)
Anne-Laura van Harmelen
(AL)
Rogier Kievit
(R)
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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