Correlation of TNF-α and TGF-β polymorphisms with protein levels in pancreatic ductal adenocarcinoma and colorectal cancer.
TGF-β (c.29C>T) polymorphism
TNF-α (c.-308G>A) polymorphism
colorectal cancer
pancreatic ductal adenocarcinoma
Journal
Contemporary oncology (Poznan, Poland)
ISSN: 1428-2526
Titre abrégé: Contemp Oncol (Pozn)
Pays: Poland
ID NLM: 101233223
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
05
2019
accepted:
22
08
2019
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
30
1
2020
Statut:
ppublish
Résumé
To determine the correlation of protein serum levels of two cytokines and their polymorphisms, which have an influence on their expression. The study group consisted of 65 patients (33 men, 31 women) who met the criteria for inclusion and exclusion of pancreatic cancer, and 41 patients (25 men, 16 women) with colorectal cancer. The control group consisted of 100 healthy volunteers (63 men, 37 women). Detection of polymorphisms was performed using TaqMan probes, and concentration of proteins by ELISA method. The mean TNF-α concentration in patients with colorectal cancer was significantly higher compared to the control group, The only statistically significant effects were the correlations between patients belonging to a specific group (pancreatic cancer/colorectal cancer/control) and average protein levels. There was no effect of sex or genotype on the occurrence of elevated levels of TNF-α and TGF-β protein control, despite their variability in particular types of cancer.
Identifiants
pubmed: 31992953
doi: 10.5114/wo.2019.91537
pii: 91537
pmc: PMC6978761
doi:
Types de publication
Journal Article
Langues
eng
Pagination
214-219Informations de copyright
Copyright © 2019 Termedia.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Front Biosci. 2008 May 01;13:5094-107
pubmed: 18508572
World J Oncol. 2019 Feb;10(1):10-27
pubmed: 30834048
J Natl Cancer Inst. 2014 Feb;106(2):djt369
pubmed: 24511106
Surg Infect (Larchmt). 2015 Dec;16(6):822-8
pubmed: 26380929
J Clin Med. 2017 Jan 18;6(1):
pubmed: 28106769
Prz Gastroenterol. 2019;14(2):89-103
pubmed: 31616522
Semin Cancer Biol. 2017 Feb;42:60-69
pubmed: 27586372
ISRN Mol Biol. 2012 Dec 24;2012:381428
pubmed: 27340590
J Leukoc Biol. 1999 Oct;66(4):562-6
pubmed: 10534109
Am J Hum Genet. 2005 May;76(5):887-93
pubmed: 15789306
Pancreatology. 2007;7(5-6):423-35
pubmed: 17898532
Clin Cancer Res. 2012 Aug 15;18(16):4266-76
pubmed: 22896693
Mediators Inflamm. 2015;2015:791060
pubmed: 26508818
Eur Cytokine Netw. 2016 Nov 1;27(4):81-89
pubmed: 28396298
Cancer Res. 2016 May 1;76(9):2525-39
pubmed: 26980767
Anticancer Res. 2010 Dec;30(12):5257-61
pubmed: 21187523
J Cancer. 2016 Oct 22;7(14):2045-2051
pubmed: 27877219
J Clin Immunol. 2002 Sep;22(5):289-96
pubmed: 12405162
N Engl J Med. 2009 Dec 17;361(25):2449-60
pubmed: 20018966
Curr Med Res Opin. 2015 Mar;31(3):557-74
pubmed: 25651481