A New Age in Molecular Diagnostics for Invasive Fungal Disease: Are We Ready?
Aspergillus PCR
CYP51A
Candida PCR
ERG11
FKS
non-culture diagnostics
whole genome sequencing antifungal resistance
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
08
2019
accepted:
02
12
2019
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
30
1
2020
Statut:
epublish
Résumé
Invasive fungal diseases (IFDs) present an increasing global burden in immunocompromised and other seriously ill populations, including those caused by pathogens which are inherently resistant or less susceptible to antifungal drugs. Early diagnosis encompassing accurate detection and identification of the causative agent and of antifungal resistance is critical for optimum patient outcomes. Many molecular-based diagnostic approaches have good clinical utility although interpretation of results should be according to clinical context. Where an IFD is in the differential diagnosis, panfungal PCR assays allow the rapid detection/identification of fungal species directly from clinical specimens with good specificity; sensitivity is also high when hyphae are seen in the specimen including in paraffin-embedded tissue.
Identifiants
pubmed: 31993022
doi: 10.3389/fmicb.2019.02903
pmc: PMC6971168
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2903Informations de copyright
Copyright © 2020 Kidd, Chen, Meyer and Halliday.
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