CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians.
Biomarkers
Senescence
Journal
NPJ aging and mechanisms of disease
ISSN: 2056-3973
Titre abrégé: NPJ Aging Mech Dis
Pays: England
ID NLM: 101678947
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
06
2019
accepted:
19
12
2019
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
30
1
2020
Statut:
epublish
Résumé
Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to analyse circulating T cells in 597 octogenarians from the same birth cohort together with NT-proBNP measurements and followed all participants over 7 years. We found that, independent of CMV serostatus, a high number of CD27-CD28+ CD8 EMRA T-lymphocytes (TEMRA) protected from all-cause death after adjusting for known risk factors, such as heart failure, frailty or cancer (Hazard ratio 0.66 for highest vs lowest tertile; confidence interval 0.51-0.86). In addition, CD27-CD28+ CD8 EMRA T-lymphocytes protected from both, non-cardiovascular (hazard ratio 0.59) and cardiovascular death (hazard ratio 0.65). In aged mice treated with the senolytic navitoclax, in which we have previously shown a rejuvenated cardiac phenotype, CD8 effector memory cells are decreased, further indicating that alterations in T cell subpopulations are associated with cardiovascular ageing. Future studies are required to show whether targeting immunosenescence will lead to enhanced life- or healthspan.
Identifiants
pubmed: 31993214
doi: 10.1038/s41514-019-0041-y
pii: 41
pmc: PMC6972903
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3Subventions
Organisme : Medical Research Council
ID : G0601333
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/15/77/31823
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0500997
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/15/12/31616
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/13/2/30154
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J50001X/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/12/31/29533
Pays : United Kingdom
Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
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