A Specific Blood Signature Reveals Higher Levels of S100A12: A Potential Bladder Cancer Diagnostic Biomarker Along With Urinary Engrailed-2 Protein Detection.

EN2 S100A12 bladder cancer lateral flow microarray plasma urine

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2019
Historique:
received: 02 10 2019
accepted: 10 12 2019
entrez: 30 1 2020
pubmed: 30 1 2020
medline: 30 1 2020
Statut: epublish

Résumé

Urothelial carcinoma of the urinary bladder (UCB) or bladder cancer remains a major health problem with high morbidity and mortality rates, especially in the western world. UCB is also associated with the highest cost per patient. In recent years numerous markers have been evaluated for suitability in UCB detection and surveillance. However, to date none of these markers can replace or even reduce the use of routine tools (cytology and cystoscopy). Our current study described UCB's extensive expression profile and highlighted the variations with normal bladder tissue. Our data revealed that

Identifiants

pubmed: 31993369
doi: 10.3389/fonc.2019.01484
pmc: PMC6962349
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1484

Informations de copyright

Copyright © 2020 Elamin, Klunkelfuß, Kämpfer, Oehlmann, Stehr, Smith, Simpson, Morgan, Pandha and Singh.

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Auteurs

Ayssar A Elamin (AA)

LIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.

Saskia Klunkelfuß (S)

LIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.

Susanne Kämpfer (S)

LIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.

Wulf Oehlmann (W)

LIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.

Matthias Stehr (M)

LIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.

Christopher Smith (C)

Department of Oncology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.

Guy R Simpson (GR)

Department of Oncology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.

Richard Morgan (R)

Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford, United Kingdom.

Hardev Pandha (H)

Department of Oncology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.

Mahavir Singh (M)

LIONEX Diagnostics and Therapeutics GmbH, Brunswick, Germany.

Classifications MeSH