Somatostatin secretion by Na
Journal
Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
30
1
2020
Statut:
ppublish
Résumé
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells
Identifiants
pubmed: 31993555
doi: 10.1038/s42255-019-0158-0
pmc: PMC6986923
mid: EMS85189
pii: 10.1038/s42255-019-0158-0
doi:
Substances chimiques
Insulin
0
Somatostatin
51110-01-1
Glucagon
9007-92-5
Sodium
9NEZ333N27
Glucose
IY9XDZ35W2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
32-40Subventions
Organisme : Medical Research Council
ID : MR/T002107/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106262
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106263/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0801995
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201325/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/3
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095531/Z/11/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201325
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/5
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 084210
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095531
Pays : United Kingdom
Organisme : Diabetes UK
ID : 12/0004622
Pays : United Kingdom
Déclaration de conflit d'intérêts
Competing interests The authors have no competing interests.
Références
Dolensek, J., Rupnik, M. S. & Stozer, A. Structural similarities and differences between the human and the mouse pancreas. Islets 7, e1024405 (2015).
doi: 10.1080/19382014.2015.1024405
Hauge-Evans, A. C. et al. Somatostatin secreted by islet δ-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes 58, 403–411 (2009).
doi: 10.2337/db08-0792
Yue, J. T. et al. Somatostatin receptor type 2 antagonism improves glucagon and corticosterone counterregulatory responses to hypoglycemia in streptozotocin-induced diabetic rats. Diabetes 61, 197–207 (2012).
doi: 10.2337/db11-0690
Cryer, P. E. Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 54, 3592–3601 (2005).
doi: 10.2337/diabetes.54.12.3592
Rorsman, P. & Huising, M. O. The somatostatin-secreting pancreatic δ-cell in health and disease. Nat. Rev. Endocrinol. 14, 404–414 (2018).
doi: 10.1038/s41574-018-0020-6
Caduff, A. et al. Dynamics of blood electrolytes in repeated hyper- and/or hypoglycaemic events in patients with type 1 diabetes. Diabetologia 54, 2678–2689 (2011).
doi: 10.1007/s00125-011-2210-9
Adriaenssens, A. E. et al. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia 59, 2156–2165 (2016).
doi: 10.1007/s00125-016-4033-1
Zhang, Q. et al. R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nat. Cell Biol. 9, 453–460 (2007).
doi: 10.1038/ncb1563
Trube, G., Rorsman, P. & Ohno-Shosaku, T. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K
doi: 10.1007/BF00657506
Vergari, E. et al. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nat. Commun. 10, 139 (2019).
doi: 10.1038/s41467-018-08193-8
van der Meulen, T. et al. Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat. Med. 21, 769–776 (2015).
doi: 10.1038/nm.3872
Zhang, Q. et al. Role of K
doi: 10.1016/j.cmet.2013.10.014
Briant, L. J. B. et al. δ-cells and β-cells are electrically coupled and regulate ɑ-cell activity via somatostatin. J. Physiol. 596, 197–215 (2018).
doi: 10.1113/JP274581
Wright, E. M., Loo, D. D. & Hirayama, B. A. Biology of human sodium glucose transporters. Physiol. Rev. 91, 733–794 (2011).
doi: 10.1152/physrev.00055.2009
Henquin, J. C. & Meissner, H. P. The electrogenic sodium-potassium pump of mouse pancreatic B-cells. J. Physiol. 332, 529–552 (1982).
doi: 10.1113/jphysiol.1982.sp014429
Unwin, R. J., Luft, F. C. & Shirley, D. G. Pathophysiology and management of hypokalemia: a clinical perspective. Nat. Rev. Nephrol. 7, 75–84 (2011).
doi: 10.1038/nrneph.2010.175
Denwood, G. et al. Glucose stimulates somatostatin secretion in pancreatic delta-cells by cAMP-dependent intracellular Ca(2+) release. J. Gen. Physiol. 151, 1094–1115 (2019).
doi: 10.1085/jgp.201912351
Rosengren, A. H. et al. Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes 61, 1726–1733 (2012).
doi: 10.2337/db11-1516
Knudsen, J. G. et al. Dysregulation of glucagon secretion by hyperglycemia-induced sodium-dependent reduction of ATP production. Cell Metab. 29, 430–442 e434 (2019).
doi: 10.1016/j.cmet.2018.10.003
Abdel-Halim, S. M., Guenifi, A., Efendic, S. & Ostenson, C. G. Both somatostatin and insulin responses to glucose are impaired in the perfused pancreas of the spontaneously noninsulin-dependent diabetic GK (Goto-Kakizaki) rats. Acta Physiol. Scand. 148, 219–226 (1993).
doi: 10.1111/j.1748-1716.1993.tb09551.x
Hermansen, K. Characterisation of the abnormal pancreatic D and A cell function in streptozotocin diabetic dogs: studies with D-glyceraldehyde, dihydroxyacetone, D-mannoheptulose, D-glucose, and L-arginine. Diabetologia 21, 489–494 (1981).
doi: 10.1007/BF00257791
Ghezzi, C., Loo, D. D. F. & Wright, E. M. Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2. Diabetologia 61, 2087–2097 (2018).
doi: 10.1007/s00125-018-4656-5
Kuhre, R. E. et al. No direct effect of SGLT2 activity on glucagon secretion. Diabetologia 62, 1011–1023 (2019).
doi: 10.1007/s00125-019-4849-6
Ghezzi, C. & Wright, E. M. Regulation of the human Na
doi: 10.1152/ajpcell.00115.2012
Bonner, C. et al. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat. Med. 21, 512–517 (2015).
doi: 10.1038/nm.3828
Ferrannini, E. et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J. Clin. Invest. 124, 499–508 (2014).
doi: 10.1172/JCI72227
Hawley, S. A. et al. The Na
doi: 10.2337/db16-0058
Hermansen, K., Lindskog, S. & Ahren, B. Stimulation of somatostatin secretion by 3-O-methylglucose in the perfused dog pancreas. Int. J. Pancreatol. 20, 103–107 (1996).
pubmed: 8968865
Rorsman, P., Ammala, C., Berggren, P. O., Bokvist, K. & Larsson, O. Cytoplasmic calcium transients due to single action-potentials and voltage-clamp depolarizations in mouse pancreatic B-cells. EMBO J. 11, 2877–2884 (1992).
doi: 10.1002/j.1460-2075.1992.tb05356.x
Palty, R. et al. NCLX is an essential component of mitochondrial Na
doi: 10.1073/pnas.0908099107
Chera, S. et al. Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Nature 514, 503–507 (2014).
doi: 10.1038/nature13633
Adam, J. et al. Fumarate hydratase deletion in pancreatic β cells leads to progressive diabetes. Cell Rep. 20, 3135–3148 (2017).
doi: 10.1016/j.celrep.2017.08.093
Schmittgen, T. D. & Livak, K. J. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 3, 1101–1108 (2008).
doi: 10.1038/nprot.2008.73
Briant, L. J. B. et al. CPT1a-dependent long-chain fatty acid oxidation contributes to maintaining glucagon secretion from pancreatic islets. Cell Rep. 23, 3300–3311 (2018).
doi: 10.1016/j.celrep.2018.05.035