mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress.
Adenylate Kinase
/ antagonists & inhibitors
Catalytic Domain
Cell Proliferation
/ physiology
Diabetes Mellitus, Type 2
/ metabolism
Down-Regulation
Enzyme Activation
Humans
Mechanistic Target of Rapamycin Complex 1
/ drug effects
Neoplasms
/ metabolism
Nutrients
/ metabolism
Phosphorylation
Schizosaccharomyces
/ metabolism
Schizosaccharomyces pombe Proteins
/ metabolism
Signal Transduction
/ physiology
Stress, Physiological
Journal
Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
entrez:
30
1
2020
pubmed:
30
1
2020
medline:
30
1
2020
Statut:
ppublish
Résumé
Central to cellular metabolism and cell proliferation are highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK)
Identifiants
pubmed: 31993556
doi: 10.1038/s42255-019-0157-1
pmc: PMC6986917
mid: EMS85173
pii: 10.1038/s42255-019-0157-1
doi:
Substances chimiques
Schizosaccharomyces pombe Proteins
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Adenylate Kinase
EC 2.7.4.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
41-49Subventions
Organisme : Worldwide Cancer Research
ID : 16-0052
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A11178
Pays : United Kingdom
Déclaration de conflit d'intérêts
Competing interests All authors declare no conflict of interest.
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