Type of Anaesthetic Influences [
Animal
Göttingen minipig
Isoflurane
PET
Propofol
Serotonin
Swine
[11C]MDL100,907
Journal
Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
30
1
2020
medline:
8
7
2021
entrez:
30
1
2020
Statut:
ppublish
Résumé
Anaesthesia routinely is used in animal neuroimaging in order to reduce head motion artefacts and minimize the influence of stress. However, anaesthetics can modify radioligand binding profiles at receptor targets studied by positron emission tomography (PET). Here, we determined the effects of two routine anaesthetics on the binding of a tracer of the serotonin 5HT Isoflurane- and propofol-anesthetised Göttingen minipigs were imaged with [ The binding potentials of the tracer in striatum under isoflurane anaesthesia significantly exceeded those obtained under propofol anaesthesia, an effect we attribute to the higher blood flow in brain induced by the former. Interactions between radioligands and anaesthesia must be carefully evaluated in the design of in vivo neuroimaging and interpretation of data.
Identifiants
pubmed: 31993926
doi: 10.1007/s11307-020-01476-x
pii: 10.1007/s11307-020-01476-x
doi:
Substances chimiques
Anesthetics
0
Biomarkers
0
Receptor, Serotonin, 5-HT2A
0
Isoflurane
CYS9AKD70P
Propofol
YI7VU623SF
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
797-804Références
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