Is bronchiectasis really a disease?
Journal
European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391
Informations de publication
Date de publication:
31 Mar 2020
31 Mar 2020
Historique:
received:
09
05
2019
accepted:
31
07
2019
entrez:
31
1
2020
pubmed:
31
1
2020
medline:
13
1
2021
Statut:
epublish
Résumé
The definition of a disease requires that distinguishing signs and symptoms are present that are common, and that the constellation of signs and symptoms differentiate the condition from other causes. In bronchiectasis, anatomical changes, airways inflammation and airway infection are the distinguishing features that are common to this disease. However, bronchiectasis is a heterogenous disease: signs and symptoms are shared with other airway diseases, there are multiple aetiologies and certain phenotypes of bronchiectasis have distinct clinical and laboratory features that are not common to all people with bronchiectasis. Furthermore, response to therapeutic interventions in clinical trials is not uniform. The concept of bronchiectasis as a treatable trait has been suggested, but this may be too restrictive in view of the heterogeneity of bronchiectasis. It is our opinion that bronchiectasis should be defined as a disease in its own right, but one that shares several pathophysiological features and "treatable traits" with other airway diseases. These traits define the large heterogeneity in the pathogenesis and clinical features and suggest a more targeted approach to therapy.
Identifiants
pubmed: 31996354
pii: 29/155/190051
doi: 10.1183/16000617.0051-2019
pmc: PMC9488738
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Chief Scientist Office
ID : SCAF/17/03
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright ©ERS 2020.
Déclaration de conflit d'intérêts
Conflict of interest: M. Shteinberg reports grants, personal fees and other funding from GSK, grants and other funding from Novartis, other funding from Actelion, grants from Trudell pharma, personal fees from Astra Zeneca and Horizon Pharma, speakers fees from Teva, other from Rafa, and personal fees and other funding from Boehringer Ingelheim, outside the submitted work. Conflict of interest: P.A. Flume reports grants and personal fees from Bayer Healthcare AG and Insmed, grants from Novoteris, and personal fees from Eloxx Pharmaceuticals and Horizon Pharma, outside the submitted work. Conflict of interest: J.D. Chalmers reports grants and personal fees from GlaxoSmithKline, Boehringer Ingelheim, AstraZeneca, Grifols/Aradigm and Insmed, personal fees from Zambon, and personal fees from Novartis, Bayer, Napp and Savara, outside the submitted work.
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