Foot-and-Mouth Disease Virus 3A Protein Causes Upregulation of Autophagy-Related Protein LRRC25 To Inhibit the G3BP1-Mediated RIG-Like Helicase-Signaling Pathway.
Animals
Autophagy
/ physiology
DNA Helicases
/ metabolism
Encephalomyocarditis virus
Enterovirus
Foot-and-Mouth Disease Virus
/ genetics
Immunity, Innate
Membrane Proteins
/ metabolism
Picornaviridae
Poly-ADP-Ribose Binding Proteins
/ metabolism
RNA Helicases
/ metabolism
RNA Recognition Motif Proteins
/ metabolism
Signal Transduction
/ physiology
Swine
Up-Regulation
Viral Proteins
/ metabolism
3A
FMDV
G3BP1
LRRC25
autophagy
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
31 03 2020
31 03 2020
Historique:
received:
12
12
2019
accepted:
14
01
2020
pubmed:
31
1
2020
medline:
29
9
2020
entrez:
31
1
2020
Statut:
epublish
Résumé
Foot-and-mouth disease virus (FMDV) is one of the most notorious pathogens in the global livestock industry. To establish an infection, FMDV needs to counteract host antiviral responses. Several studies have shown how FMDV suppresses the type I interferon (IFN) response; however, whether FMDV modulates the integrated autophagy and innate immunity remains largely unknown. Here, the porcine Ras-GAP SH3-binding protein 1 (G3BP1) was shown to promote the retinoic acid-inducible gene I (RIG-I)-like helicase (RLH) signaling by upregulating the expression of RIG-I and melanoma differentiation-associated gene 5 (MDA5). FMDV nonstructural protein 3A interacted with G3BP1 to inhibit G3BP1 expression and G3BP1-mediated RLH signaling by upregulating the expression of autophagy-related protein LRRC25. In addition, 3A proteins of other picornaviruses, including Seneca Valley virus (SVV) 3A, enterovirus 71 (EV71) 3A, and encephalomyocarditis virus (EMCV) 3A, also showed similar actions. Taking the data together, we elucidated, for the first time, a novel mechanism by which FMDV has evolved to inhibit IFN signaling and counteract host innate antiviral responses by autophagy.
Identifiants
pubmed: 31996428
pii: JVI.02086-19
doi: 10.1128/JVI.02086-19
pmc: PMC7108857
pii:
doi:
Substances chimiques
Membrane Proteins
0
Poly-ADP-Ribose Binding Proteins
0
RNA Recognition Motif Proteins
0
Viral Proteins
0
DNA Helicases
EC 3.6.4.-
RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Yang et al.
Références
J Gen Virol. 2004 Oct;85(Pt 10):2953-2962
pubmed: 15448358
Cell Cycle. 2016;15(6):850-60
pubmed: 26901336
Nat Immunol. 2019 Jan;20(1):18-28
pubmed: 30510222
J Virol. 2001 Feb;75(3):1551-6
pubmed: 11152528
J Biol Chem. 2019 Apr 19;294(16):6430-6438
pubmed: 30804210
J Virol. 2011 Apr;85(8):3758-66
pubmed: 21307201
FASEB J. 2016 May;30(5):1757-66
pubmed: 26813975
Nat Immunol. 2004 Jul;5(7):730-7
pubmed: 15208624
Vet Res. 2013 Dec 05;44:116
pubmed: 24308718
Immunity. 2008 Aug 15;29(2):178-81
pubmed: 18701081
J Virol. 2019 Jun 14;93(13):
pubmed: 30996089
Comp Immunol Microbiol Infect Dis. 2002 Oct;25(5-6):297-308
pubmed: 12365806
Sci Rep. 2016 Feb 17;6:21888
pubmed: 26883855
J Exp Med. 2017 Apr 3;214(4):973-989
pubmed: 28250012
J Cell Biol. 2003 Mar 17;160(6):823-31
pubmed: 12642610
Biochem Biophys Res Commun. 2010 Aug 13;399(1):72-8
pubmed: 20638368
J Hyg (Lond). 1978 Aug;81(1):107-23
pubmed: 211160
J Virol. 2019 Jul 30;93(16):
pubmed: 31167908
J Gen Virol. 2004 Sep;85(Pt 9):2567-2575
pubmed: 15302950
Arch Virol. 2014 Nov;159(11):2925-35
pubmed: 25085622
J Gen Virol. 2001 Apr;82(Pt 4):747-755
pubmed: 11257178
Front Immunol. 2018 May 25;9:1142
pubmed: 29887867
Immunity. 2018 Sep 18;49(3):438-448.e5
pubmed: 30193849
Virology. 2012 Mar 30;425(1):40-52
pubmed: 22280896
J Virol. 2004 Apr;78(7):3271-8
pubmed: 15016848
J Virol. 2019 Jan 4;93(2):
pubmed: 30404792
J Biol Chem. 2018 May 25;293(21):7942-7968
pubmed: 29626090
J Biol Chem. 2004 Apr 16;279(16):16847-53
pubmed: 14754897
Autophagy. 2018;14(2):336-346
pubmed: 29166823
Virus Res. 2011 Jul;159(1):9-16
pubmed: 21539869
Mol Immunol. 2011 Oct;49(1-2):407-12
pubmed: 21975014
Mol Ther Nucleic Acids. 2019 Jun 7;16:105-117
pubmed: 30861413
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17264-9
pubmed: 15563593
FEBS J. 2017 Oct;284(19):3202-3217
pubmed: 28755480
EMBO J. 2018 Feb 1;37(3):351-366
pubmed: 29288164
Cell Death Differ. 2019 Aug;26(8):1411-1427
pubmed: 30442948
J Virol. 2014 May;88(9):4908-20
pubmed: 24554650
J Immunol. 2016 Jul 1;197(1):199-207
pubmed: 27194789
Am J Cancer Res. 2016 Nov 01;6(11):2641-2650
pubmed: 27904777
J Virol. 2012 Sep;86(17):9311-22
pubmed: 22718831