The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome.
Animals
Autophagy
Brain
/ metabolism
Chlorocebus aethiops
Endoplasmic Reticulum
/ immunology
Endoplasmic Reticulum Stress
/ immunology
Glycoproteins
/ genetics
Glycosylation
HEK293 Cells
Hemorrhagic Fever, American
/ virology
Hemorrhagic Fevers, Viral
/ prevention & control
Humans
Junin virus
/ genetics
Lysosomes
/ metabolism
Mice
Mutation
Vaccines, Attenuated
/ immunology
Vero Cells
Viral Envelope Proteins
/ genetics
Viral Vaccines
/ immunology
Junin virus
arenavirus
glycoproteins
hemorrhagic fever
vaccines
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
31 03 2020
31 03 2020
Historique:
received:
02
10
2019
accepted:
24
01
2020
pubmed:
31
1
2020
medline:
29
9
2020
entrez:
31
1
2020
Statut:
epublish
Résumé
Argentine hemorrhagic fever is a potentially lethal disease that is caused by Junin virus (JUNV). There are currently around 5 million individuals at risk of infection within regions of endemicity in Argentina. The live attenuated vaccine strain Candid #1 (Can) is approved for use in regions of endemicity and has substantially decreased the number of annual Argentine hemorrhagic fever (AHF) cases. The glycoprotein (GPC) gene is primarily responsible for attenuation of the Can strain, and we have shown that the absence of an
Identifiants
pubmed: 31996435
pii: JVI.01693-19
doi: 10.1128/JVI.01693-19
pmc: PMC7108856
pii:
doi:
Substances chimiques
Glycoproteins
0
Vaccines, Attenuated
0
Viral Envelope Proteins
0
Viral Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI093445
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001440
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Microbiology.
Références
J Virol. 2009 Jun;83(11):5606-14
pubmed: 19321606
Nat Rev Mol Cell Biol. 2005 Jan;6(1):79-87
pubmed: 15688069
Virus Res. 1994 Dec;34(3):317-26
pubmed: 7856317
J Virol. 2011 Feb;85(4):1473-83
pubmed: 21123388
Front Cell Infect Microbiol. 2017 Feb 06;7:20
pubmed: 28220142
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12701-5
pubmed: 11606739
Hum Vaccin. 2011 Jun;7(6):694-700
pubmed: 21451263
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
Curr Top Microbiol Immunol. 2002;262:159-73
pubmed: 11987805
J Virol. 2001 Oct;75(19):9415-26
pubmed: 11533204
J Virol. 2007 Sep;81(17):9451-60
pubmed: 17581989
Curr Genomics. 2013 Nov;14(7):415-24
pubmed: 24396274
Am J Trop Med Hyg. 2008 Aug;79(2):275-82
pubmed: 18689636
Viruses. 2012 Nov 09;4(11):2973-3011
pubmed: 23202512
Int J Cell Biol. 2012;2012:189794
pubmed: 22536246
Dis Model Mech. 2014 Mar;7(3):331-41
pubmed: 24609034
J Virol. 2015 Jun;89(11):5949-56
pubmed: 25810546
J Virol. 2011 Feb;85(4):1662-70
pubmed: 21106748
J Virol. 2011 Dec;85(24):13457-62
pubmed: 21976641
J Virol. 2011 Oct;85(19):10404-8
pubmed: 21795336
J Biochem. 1996 Mar;119(3):572-6
pubmed: 8830056
J Virol. 2006 Sep;80(18):9192-9
pubmed: 16940530
PLoS One. 2014 Jun 11;9(6):e99610
pubmed: 24918927
J Virol. 2012 Aug;86(15):7728-38
pubmed: 22532683
Virus Genes. 2010 Jun;40(3):320-8
pubmed: 20148301