Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation.
4-Chloro-7-nitrobenzofurazan
/ analogs & derivatives
AMP-Activated Protein Kinase Kinases
Abscisic Acid
/ metabolism
Animals
Cell Line
Deoxyglucose
/ analogs & derivatives
Diabetes Mellitus
/ metabolism
Disease Models, Animal
Glucose
/ metabolism
Insulin
/ metabolism
Male
Membrane Proteins
/ genetics
Mice
Mice, Inbred C57BL
Mice, Knockout
Muscle, Skeletal
/ pathology
Myoblasts
/ metabolism
Protein Kinases
/ metabolism
RNA, Small Interfering
/ genetics
Rats
Rats, Wistar
TRPM Cation Channels
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 01 2020
29 01 2020
Historique:
received:
31
07
2019
accepted:
07
01
2020
entrez:
31
1
2020
pubmed:
31
1
2020
medline:
14
7
2020
Statut:
epublish
Résumé
Abscisic acid (ABA) is a plant hormone active also in mammals where it regulates, at nanomolar concentrations, blood glucose homeostasis. Here we investigated the mechanism through which low-dose ABA controls glycemia and glucose fate. ABA stimulated uptake of the fluorescent glucose analog 2-NBDG by L6, and of [
Identifiants
pubmed: 31996711
doi: 10.1038/s41598-020-58206-0
pii: 10.1038/s41598-020-58206-0
pmc: PMC6989460
doi:
Substances chimiques
Insulin
0
LANCL2 protein, rat
0
Membrane Proteins
0
RNA, Small Interfering
0
TRPM Cation Channels
0
TRPM2 protein, mouse
0
Abscisic Acid
72S9A8J5GW
Deoxyglucose
9G2MP84A8W
Protein Kinases
EC 2.7.-
AMP-Activated Protein Kinase Kinases
EC 2.7.11.3
4-Chloro-7-nitrobenzofurazan
EQF2794IRE
Glucose
IY9XDZ35W2
2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose
JE4F4P486R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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