Protective effects of losartan on some type 2 diabetes mellitus-induced complications in Wistar and spontaneously hypertensive rats.
Angiotensin II Type 1 Receptor Blockers
/ administration & dosage
Animals
Brain
/ drug effects
Corticosterone
/ blood
Diabetes Mellitus, Experimental
/ complications
Diabetes Mellitus, Type 2
/ complications
Diet, High-Fat
Exploratory Behavior
/ drug effects
Insulin Resistance
Insulin Secretion
/ drug effects
Losartan
/ administration & dosage
Memory
/ drug effects
Nociception
/ drug effects
Rats
Rats, Inbred SHR
Rats, Wistar
Anxiety
Diabetes mellitus type 2
Losartan
Memory
Renin Angiotensin Aldosterone System
Journal
Metabolic brain disease
ISSN: 1573-7365
Titre abrégé: Metab Brain Dis
Pays: United States
ID NLM: 8610370
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
03
04
2019
accepted:
17
01
2020
pubmed:
31
1
2020
medline:
3
2
2021
entrez:
31
1
2020
Statut:
ppublish
Résumé
Diabetes mellitus type 2 (T2DM) is characterized by resistance of insulin receptors and/or inadequate insulin secretion resulting in metabolic and structural complications including vascular diseases, arterial hypertension and different behavioral alterations. We aimed to study the effects of the antihypertensive angiotensin AT1 receptor antagonist losartan on the T2DM-induced changes of exploratory behavior, anxiety, nociception and short term memory in normotensive Wistar and spontaneously hypertensive rats (SHRs). The experimental model of T2DM induced by a combination of high fat diet and streptozotocin, decreased exploratory activity and increased the level of carbonylated proteins in selected brain structures in both strains; as well it increased corticosterone level, pain threshold, anxiety-like behavior, and decline short term memory only in SHRs. Losartan treatment alleviated some of the T2DM- induced metabolic complications, abolished the T2DM-induced hypo activity, and normalized the corticosterone level, carbonylated proteins in brain, nociception and memory. Losartan did not exert effect on the anxiety behavior in both strains. We showed that T2DM exerted more pronounced negative effects on the rats with comorbid hypertension as compared to normotensive rats. Overall effects on the studied behavioral parameters are related to decreased exploration of the new environment, increased anxiety-like behavior, and decline in short-term memory. The systemic sub-chronic treatment with an angiotensin AT1 receptor antagonist losartan ameliorated most of these complications.
Identifiants
pubmed: 31997264
doi: 10.1007/s11011-020-00534-1
pii: 10.1007/s11011-020-00534-1
doi:
Substances chimiques
Angiotensin II Type 1 Receptor Blockers
0
Losartan
JMS50MPO89
Corticosterone
W980KJ009P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
527-538Références
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