Polygenic score for neuroticism is related to sleep difficulties.
neuroticism
polygenic score
sleep quality
Journal
Genes, brain, and behavior
ISSN: 1601-183X
Titre abrégé: Genes Brain Behav
Pays: England
ID NLM: 101129617
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
14
08
2019
revised:
23
01
2020
accepted:
25
01
2020
pubmed:
31
1
2020
medline:
3
2
2021
entrez:
31
1
2020
Statut:
ppublish
Résumé
Neuroticism, a broad trait measure of the tendency to experience negative emotions and vulnerability to stress, is consistently related to poor sleep quality. Less is known about potential pleiotropy in the genetic risk for high neuroticism and poor sleep. Therefore, the present study examined whether polygenic score (PGS) for neuroticism is related to sleep quality in two large samples of adults. In addition, depressive symptoms, anxiety and phenotypical neuroticism were tested as mediators in both samples. Participants were 8316 individuals aged from 50 to 101 years (mean age = 68.29, SD = 9.83) from the Health and Retirement Study, and 4973 individuals aged from 63 to 67 years (mean age = 64.30, SD = 0.68) from the Wisconsin Longitudinal Study. Participants from both samples were genotyped and answered questions on sleep quality. A higher PGS for neuroticism was related to lower sleep quality concurrently and over time in both samples. Anxiety, depressive symptoms and neuroticism mediated these relationships in the two samples. Although effect sizes were small, the present study provides replicable evidence that individuals with a higher genetic predisposition to experience negative emotions and distress are at risk of sleep difficulties.
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12644Subventions
Organisme : NIA NIH HHS
ID : NIA-U01AG009740
Pays : United States
Organisme : NIA NIH HHS
ID : AG-041868
Pays : United States
Organisme : NIA NIH HHS
ID : AG-033285
Pays : United States
Organisme : NIA NIH HHS
ID : AG-21079
Pays : United States
Organisme : NIA NIH HHS
ID : AG-9775
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
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