Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice.
auditory cortex
consonant
discrimination
neural coding
optogenetic
speech perception
speech – brain
spike time coding
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
09
2019
accepted:
10
12
2019
entrez:
31
1
2020
pubmed:
31
1
2020
medline:
31
1
2020
Statut:
epublish
Résumé
Speech evokes robust activity in auditory cortex, which contains information over a wide range of spatial and temporal scales. It remains unclear which components of these neural representations are causally involved in the perception and processing of speech sounds. Here we compared the relative importance of early and late speech-evoked activity for consonant discrimination. We trained mice to discriminate the initial consonants in spoken words, and then tested the effect of optogenetically suppressing different temporal windows of speech-evoked activity in auditory cortex. We found that both early and late suppression disrupted performance equivalently. These results suggest that mice are impaired at recognizing either type of disrupted representation because it differs from those learned in training.
Identifiants
pubmed: 31998064
doi: 10.3389/fnins.2019.01394
pmc: PMC6965026
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1394Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC015828
Pays : United States
Informations de copyright
Copyright © 2020 O’Sullivan, Weible and Wehr.
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