Is the Retina a Mirror of the Aging Brain? Aging of Neural Retina Layers and Primary Visual Cortex Across the Lifespan.
ganglion cell layer (GCL)
healthy aging
magnetic resonance imaging (MRI)
optical coherence tomography (OCT)
outer segment photoreceptor/RPE complex (OPR)
primary visual cortex (BA17)
retinal segmentation
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
08
2019
accepted:
10
12
2019
entrez:
31
1
2020
pubmed:
31
1
2020
medline:
31
1
2020
Statut:
epublish
Résumé
How aging concomitantly modulates the structural integrity of the brain and retina in healthy individuals remains an outstanding question. Given the strong bottom-up retinocortical connectivity, it is important to study how these structures co-evolve during healthy aging in order to unravel mechanisms that may affect the physiological integrity of both structures. For the 56 participants in the study, primary visual cortex (BA17), as well as frontal, parietal and temporal regions thicknesses were measured in T1-weighted magnetic resonance imaging (MRI), and retinal macular thickness (10 neuroretinal layers) was measured by optical coherence tomography (OCT) imaging. We investigated the statistical association of these measures and their age dependence. We found an age-related decay of primary visual cortical thickness that was significantly correlated with a decrease in global and multiple layer retinal thicknesses. The atrophy of both structures might jointly account for the decline of various visual capacities that accompany the aging process. Furthermore, associations with other cortical regions suggest that retinal status may index cortical integrity in general.
Identifiants
pubmed: 31998115
doi: 10.3389/fnagi.2019.00360
pmc: PMC6961569
doi:
Types de publication
Journal Article
Langues
eng
Pagination
360Informations de copyright
Copyright © 2020 Jorge, Canário, Quental, Bernardes and Castelo-Branco.
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