Human Atrial Fibroblast Adaptation to Heterogeneities in Substrate Stiffness.
fibrosis
hydrogel
light-tunable
mechanosensing
nanoindentation
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
05
2019
accepted:
04
12
2019
entrez:
31
1
2020
pubmed:
31
1
2020
medline:
31
1
2020
Statut:
epublish
Résumé
Fibrosis is associated with aging and many cardiac pathologies. It is characterized both by myofibroblast differentiation and by excessive accumulation of extracellular matrix proteins. Fibrosis-related tissue remodeling results in significant changes in tissue structure and function, including passive mechanical properties. This research area has gained significant momentum with the recent development of new tools and approaches to better characterize and understand the ability of cells to sense and respond to their biophysical environment. We use a novel hydrogel, termed CyPhyGel, to provide an advanced
Identifiants
pubmed: 31998137
doi: 10.3389/fphys.2019.01526
pmc: PMC6965062
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1526Informations de copyright
Copyright © 2020 Emig, Zgierski-Johnston, Beyersdorf, Rylski, Ravens, Weber, Kohl, Hörner and Peyronnet.
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