Seasonal Changes of Serum Gonadotropins and Testosterone in Men Revealed by a Large Data Set of Real-World Observations Over Nine Years.
daylight cycle
follicle stimulating hormone
luteinizing hormone
seasonal variation
testosterone
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
07
2019
accepted:
16
12
2019
entrez:
31
1
2020
pubmed:
31
1
2020
medline:
31
1
2020
Statut:
epublish
Résumé
Environmental rhythmicity is able to affect the hypothalamic-pituitary-gonadal axis in several animals to achieve reproductive advantages. However, conflicting results were obtained when assessing the environmental-dependent rhythmicity on reproductive hormone secretion in humans. This study was designed to evaluate seasonal fluctuations of the main hormones involved in the hypothalamic-pituitary-gonadal axis in men, using a big data approach. An observational, retrospective, big data trial was carried out, including all testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) measurements performed in a single laboratory between January 2010 and January 2019 using Chemiluminescent Microparticle Immunoassay. Subjects presenting any factor interfering with the hypothalamic-pituitary-gonadal axis were excluded. The trend and seasonal distributions were analyzed using autoregressive integrated moving average (ARIMA) models. A total of 12,033 data, accounting for 7,491 men (mean age 47.46 ± 13.51 years, range 18-91 years) were included. Testosterone serum levels (mean 5.34 ± 2.06 ng/dL, range 1.70-15.80 ng/dL) showed a seasonal distribution with higher levels in summer and a direct correlation to environmental temperatures and daylight duration. LH levels (mean 4.64 ± 2.54 IU/L, range 1.00-15.00 IU/L) presented 2 peaks of secretion in autumn and spring, independently from environmental parameters. FSH levels (mean 5.51 ± 3.24 IU/L) did not show any seasonal distribution. A clear seasonal fluctuation of both LH and testosterone was demonstrated in a large cohort of adult men, although a circannual seasonality of hypothalamic-pituitary-gonadal hormones in humans could be not strictly evolutionarily required. Testosterone seasonality seems independent from LH fluctuations, which could be regulated by cyclic central genes expression, and more sensible to environmental temperatures and daylight duration.
Identifiants
pubmed: 31998242
doi: 10.3389/fendo.2019.00914
pmc: PMC6965064
doi:
Types de publication
Journal Article
Langues
eng
Pagination
914Informations de copyright
Copyright © 2020 Santi, Spaggiari, Granata, Setti, Tagliavini, Trenti and Simoni.
Références
J Androl. 2012 Nov-Dec;33(6):1111-8
pubmed: 22879528
J Androl. 2002 Jan-Feb;23(1):64-70
pubmed: 11780924
J Biol Rhythms. 2001 Aug;16(4):348-64
pubmed: 11506380
Res Nurs Health. 1990 Dec;13(6):429-35
pubmed: 2270308
J Biol Rhythms. 1990 Fall;5(3):217-39
pubmed: 2133133
Med Sci Sports Exerc. 1994 Jul;26(7):929-33
pubmed: 7934770
Trends Endocrinol Metab. 2015 Oct;26(10):564-572
pubmed: 26412157
Cell. 1999 Jan 22;96(2):271-90
pubmed: 9988221
J Neuroendocrinol. 2014 Jul;26(7):459-67
pubmed: 24824153
Int J Chronobiol. 1981;7(3):165-88
pubmed: 7239725
Metabolism. 2000 Aug;49(8):1085-91
pubmed: 10954031
Am J Epidemiol. 1981 Dec;114(6):804-16
pubmed: 7315829
Environ Pollut. 2018 Apr;235:806-813
pubmed: 29353799
J Clin Endocrinol Metab. 2003 Jul;88(7):3099-104
pubmed: 12843149
J Mol Histol. 2009 Apr;40(2):123-30
pubmed: 19484498
Neuroendocrinology. 2011;93(4):211-22
pubmed: 21508622
Clin Endocrinol (Oxf). 1992 Jan;36(1):29-34
pubmed: 1559297
Int J Chronobiol. 1981;8(1):31-48
pubmed: 7341496
Br J Math Stat Psychol. 2018 Feb;71(1):96-116
pubmed: 28898401
PLoS One. 2019 Oct 7;14(10):e0223366
pubmed: 31589630
PLoS One. 2019 May 9;14(5):e0216462
pubmed: 31071156
Int J Biometeorol. 1998 Aug;42(1):51-4
pubmed: 9780846
Acta Endocrinol (Copenh). 1985 Aug;109(4):446-50
pubmed: 3929512
Neural Netw. 2016 Mar;75:126-40
pubmed: 26775131
Biol Reprod. 1998 Feb;58(2):492-6
pubmed: 9475406
PLoS One. 2010 Apr 02;5(4):e10007
pubmed: 20368993
PLoS Comput Biol. 2013;9(2):e1002940
pubmed: 23468616
J Endocrinol Invest. 2013 May;36(5):339-42
pubmed: 23013937
Cell. 2006 May 5;125(3):497-508
pubmed: 16678094
J Pineal Res. 1997 Mar;22(2):95-101
pubmed: 9181521
Eur J Endocrinol. 2012 Jan;166(1):77-85
pubmed: 22048968
Clin Endocrinol (Oxf). 1997 May;46(5):587-98
pubmed: 9231055
Life Sci. 2016 Feb 1;146:184-91
pubmed: 26739509
Hum Reprod. 1996 Feb;11(2):248-52
pubmed: 8671203
J Clin Endocrinol Metab. 1976 May;42(5):979-82
pubmed: 1270587
Genus. 1985 Jul-Dec;41(3-4):127-33
pubmed: 12280403
Annu Rev Physiol. 2010;72:517-49
pubmed: 20148687
Clin Endocrinol (Oxf). 1983 Oct;19(4):453-9
pubmed: 6414746
Fertil Steril. 1988 Feb;49(2):309-15
pubmed: 3123279
Asian J Androl. 2010 Jul;12(4):605-6
pubmed: 20543855
Chronobiol Int. 1990;7(3):245-9
pubmed: 2268886
Hum Reprod. 2000 Jan;15(1):60-5
pubmed: 10611189
Endocrinologie. 1985 Oct-Dec;23(4):223-46
pubmed: 2935925
Nature. 2007 Dec 13;450(7172):1086-90
pubmed: 18075593
Andrologia. 1987 May-Jun;19(3):353-61
pubmed: 3115144
Gen Comp Endocrinol. 2018 Sep 1;265:149-153
pubmed: 29625122