Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future Opportunities.
cancer
dendritic cells
immune responses
immunotherapy
inflammation
macrophages
pathogens
trained immunity
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
06
2019
accepted:
04
12
2019
entrez:
31
1
2020
pubmed:
31
1
2020
medline:
31
1
2020
Statut:
epublish
Résumé
Memory formation, guided by microbial ligands, has been reported for innate immune cells. Epigenetic imprinting plays an important role herein, involving histone modification after pathogen-/danger-associated molecular patterns (PAMPs/DAMPs) recognition by pattern recognition receptors (PRRs). Such "trained immunity" affects not only the nominal target pathogen, yet also non-related targets that may be encountered later in life. The concept of trained innate immunity warrants further exploration in cancer and how these insights can be implemented in immunotherapeutic approaches. In this review, we discuss our current understanding of innate immune memory and we reference new findings in this field, highlighting the observations of trained immunity in monocytic and natural killer cells. We also provide a brief overview of trained immunity in non-immune cells, such as stromal cells and fibroblasts. Finally, we present possible strategies based on trained innate immunity that may help to devise host-directed immunotherapies focusing on cancer, with possible extension to infectious diseases.
Identifiants
pubmed: 31998254
doi: 10.3389/fmicb.2019.02924
pmc: PMC6967396
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2924Informations de copyright
Copyright © 2020 Lérias, de Sousa, Paraschoudi, Martins, Condeço, Figueiredo, Carvalho, Dodoo, Maia, Castillo-Martin, Beltrán, Ligeiro, Rao, Zumla and Maeurer.
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