A Summary Report of FSCJ Workshop "Future Challenges and Opportunities in Developing Methodologies for Improved Human Risk Assessments".
PBPK modeling
TTC
food safety risk assessments
read-across
risk assessment methodologies
toxicological databases
Journal
Food safety (Tokyo, Japan)
ISSN: 2187-8404
Titre abrégé: Food Saf (Tokyo)
Pays: Japan
ID NLM: 101685527
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
31
01
2019
accepted:
08
10
2019
entrez:
31
1
2020
pubmed:
31
1
2020
medline:
31
1
2020
Statut:
epublish
Résumé
This is a summary report of FSCJ (Food Safety Commission of Japan) workshop entitled "Future Challenges and Opportunities in Developing Methodologies for Improved Human Risk Assessments, which held in November 2018. Scientific advancements have facilitated the development of new methods for chemical risk assessments with the expansion of toxicological databases. They are promising tools to overcome challenges, such as situations of data insufficiency, estimation of internal exposure and prediction of hazard, and enable us to improve our human health risk assessment in food safety. In this review, current understandings on developments in chemical risk assessments, especially focusing on Threshold of Toxicological Concern (TTC) approach, non-testing and
Identifiants
pubmed: 31998592
doi: 10.14252/foodsafetyfscj.2018017
pii: 2018017
pmc: PMC6957455
doi:
Types de publication
Journal Article
Langues
eng
Pagination
83-89Informations de copyright
©2019 Food Safety Commission, Cabinet Office, Government of Japan.
Déclaration de conflit d'intérêts
Conflict of interest statement: The authors had no conflicts of interest to declare in this article. Disclaimer: The content of this article reflect solely the views of the authors. The views presented in this article do not necessarily reflect the current or future opinion or policy of the U.S. Food and Drug Administration. Any mention of commercial products is for clarification and not intended as an endorsement.
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