Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies-Activities Against Blood Stage

amino-artemisinins gametocytes malaria sporozoites transmission-blocking

Journal

Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988

Informations de publication

Date de publication:
2019
Historique:
received: 01 09 2019
accepted: 13 12 2019
entrez: 31 1 2020
pubmed: 31 1 2020
medline: 31 1 2020
Statut: epublish

Résumé

We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives dihydroartemisinin (DHA), artemether and artesunate, display potent activities

Identifiants

DOI: 10.3389/fchem.2019.00901 PMID: 31998692 PMC: PMC6967409
pubmed: 31998692
doi: 10.3389/fchem.2019.00901
pmc: PMC6967409
doi:

Types de publication

Journal Article

Langues

eng

Pagination

901

Informations de copyright

Copyright © 2020 Wong, Padín-Irizarry, van der Watt, Reader, Liebenberg, Wiesner, Smith, Eribez, Winzeler, Kyle, Birkholtz, Coertzen and Haynes.

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Auteurs

Ho Ning Wong (HN)

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Vivian Padín-Irizarry (V)

Center for Tropical & Emerging Global Diseases, Coverdell Center, University of Georgia, Athens, GA, United States.

Mariëtte E van der Watt (ME)

Malaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.

Janette Reader (J)

Malaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.

Wilna Liebenberg (W)

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Lubbe Wiesner (L)

Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Peter Smith (P)

Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Korina Eribez (K)

School of Medicine, University of California, San Diego, La Jolla, CA, United States.

Elizabeth A Winzeler (EA)

School of Medicine, University of California, San Diego, La Jolla, CA, United States.

Dennis E Kyle (DE)

Center for Tropical & Emerging Global Diseases, Coverdell Center, University of Georgia, Athens, GA, United States.

Lyn-Marie Birkholtz (LM)

Malaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.

Dina Coertzen (D)

Malaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.

Richard K Haynes (RK)

Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Classifications MeSH