Elevated serum glycated albumin and glycated albumin : hemoglobin A
Aged
Analysis of Variance
Atrophy
Brain
/ diagnostic imaging
Dementia
/ blood
Female
Geriatric Assessment
Glycated Hemoglobin
/ analysis
Glycation End Products, Advanced
Hippocampus
/ diagnostic imaging
Humans
Japan
Longitudinal Studies
Magnetic Resonance Imaging
Male
Organ Size
Serum Albumin
/ analysis
Glycated Serum Albumin
Dementia
Magnetic resonance imaging
Risk factors in epidemiology
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
05
10
2019
revised:
07
01
2020
accepted:
26
01
2020
pubmed:
31
1
2020
medline:
7
7
2021
entrez:
31
1
2020
Statut:
ppublish
Résumé
To investigate the association of alternative glycemic measures - namely, serum glycated albumin (GA), hemoglobin A A total of 1,278 Japanese individuals aged ≥65 years in a community participated in brain magnetic resonance imaging scanning and screening examination of health status in 2012. We measured total brain volume (TBV), hippocampal volume (HV) and intracranial volume (ICV) using the data from the magnetic resonance imaging examination. The association of each glycemic measure with the ratios of TBV : ICV (an indicator of global brain atrophy) and HV : ICV (an indicator of hippocampal atrophy) was examined by analysis of covariance. The mean values of the TBV : ICV and HV : ICV ratios decreased significantly with elevating serum GA levels and GA : HbA The present study suggests that higher serum GA and higher GA : HbA
Identifiants
pubmed: 31999889
doi: 10.1111/jdi.13220
pmc: PMC7378434
doi:
Substances chimiques
Glycated Hemoglobin A
0
Glycation End Products, Advanced
0
Serum Albumin
0
hemoglobin A1c protein, human
0
Glycated Serum Albumin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
971-979Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP19dk0207025
Organisme : Japan Agency for Medical Research and Development
ID : JP19ek0210080
Organisme : Japan Agency for Medical Research and Development
ID : JP19ek0210082
Organisme : Japan Agency for Medical Research and Development
ID : JP19ek0210083
Organisme : Japan Agency for Medical Research and Development
ID : JP19fk0108075
Organisme : Japan Agency for Medical Research and Development
ID : JP19km0405202
Organisme : Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan
ID : H29-Junkankitou-Ippan-003
Organisme : Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan
ID : H30-Shokuhin-[Sitei]-005
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP16H02692
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP16H05850
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP17H04126
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP17K01853
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP17K09113
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP17K09114
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP18H02737
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP18K07565
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP18K09412
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP18K17382
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP18K17925
Organisme : Grants-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : JP19K07890
Informations de copyright
© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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