Dermal and Intraepidermal Merkel Cell Carcinoma With Squamous Cell Carcinoma: A Report of a Rare Case With Special Reference to the Touch Dome.
Aged, 80 and over
Biomarkers, Tumor
/ analysis
Carcinoma, Merkel Cell
/ chemistry
Carcinoma, Squamous Cell
/ chemistry
Cell Lineage
Female
Humans
Immunohistochemistry
Keratins
/ analysis
Merkel Cells
/ chemistry
Neoplasms, Complex and Mixed
/ chemistry
Neoplastic Stem Cells
/ chemistry
Skin Neoplasms
/ chemistry
Journal
The American Journal of dermatopathology
ISSN: 1533-0311
Titre abrégé: Am J Dermatopathol
Pays: United States
ID NLM: 7911005
Informations de publication
Date de publication:
01 Jan 2021
01 Jan 2021
Historique:
pubmed:
31
1
2020
medline:
7
10
2021
entrez:
31
1
2020
Statut:
ppublish
Résumé
In skin containing hair follicles, specialized epithelial structures known as "touch domes (TDs)" are located where the Merkel cells are clustered. We explored the histogenetic relationship between intraepidermal and dermal Merkel cell carcinomas (MCCs) and investigated which transformed progenitor cells can develop into intraepidermal MCC. We encountered an association between an extremely rare case of dermal and intraepidermal MCC with squamous cell carcinoma, which was examined using standard immunohistochemical methods with various epithelial, neuroendocrine, and TD markers including several immunohistochemical markers. Differential expression levels of CK20 and CD56 were found between intraepidermal and dermal MCCs, indicating molecularly distinct MCC populations. CK15 and CK17, expressed in TDs, were partially expressed in the intraepidermal neuroendocrine component at the tumor periphery in intraepidermal MCC with squamous cell carcinoma. These differences may suggest that the origin of dermal and intraepidermal MCCs is different under pathological conditions. We hypothesize that intraepidermal MCC is derived from tissue-specific stem cells localized within TDs.
Identifiants
pubmed: 32000217
pii: 00000372-202101000-00003
doi: 10.1097/DAD.0000000000001618
doi:
Substances chimiques
Biomarkers, Tumor
0
Keratins
68238-35-7
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-20Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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