N-Terminal Proteoforms in Human Disease.

Alternative Splicing Humans Protein Biosynthesis Protein Processing, Post-Translational
N-terminal modifications N-terminal proteoforms alternative splicing alternative translation initiation protein N termini

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
04 2020
Historique:
received: 25 10 2019
revised: 06 12 2019
accepted: 31 12 2019
pubmed: 1 2 2020
medline: 18 9 2021
entrez: 1 2 2020
Statut: ppublish

Résumé

The collection of chemically different protein variants, or proteoforms, by far exceeds the number of protein-coding genes in the human genome. Major contributors are alternative splicing and protein modifications. In this review, we focus on those proteoforms that differ at their N termini with a molecular link to disease. We describe the main underlying mechanisms that give rise to such N-terminal proteoforms, these being splicing, initiation of protein translation, and protein modifications. Given their role in several human diseases, it is becoming increasingly clear that several of these N-terminal proteoforms may have potential as therapeutic interventions and/or for diagnosing and prognosing their associated disease.

Identifiants

DOI: 10.1016/j.tibs.2019.12.009 PMID: 32001092
pubmed: 32001092
pii: S0968-0004(20)30007-4
doi: 10.1016/j.tibs.2019.12.009
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

308-320

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Annelies Bogaert (A)

VIB Center for Medical Biotechnology, VIB, B-9000 Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, B-9000 Ghent, Belgium.

Esperanza Fernandez (E)

VIB Center for Medical Biotechnology, VIB, B-9000 Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, B-9000 Ghent, Belgium.

Kris Gevaert (K)

VIB Center for Medical Biotechnology, VIB, B-9000 Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, B-9000 Ghent, Belgium. Electronic address: kris.gevaert@vib-ugent.be.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Épissage alternatif › N-Terminal Proteoforms in Human Disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › N-Terminal Proteoforms in Human Disease.
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › N-Terminal Proteoforms in Human Disease.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › N-Terminal Proteoforms in Human Disease.