Copper sulfate-induced endoplasmic reticulum stress promotes hepatic apoptosis by activating CHOP, JNK and caspase-12 signaling pathways.

Animals Apoptosis / drug effects Caspase 12 / metabolism Copper Sulfate / toxicity Dose-Response Relationship, Drug Endoplasmic Reticulum Chaperone BiP Endoplasmic Reticulum Stress / drug effects JNK Mitogen-Activated Protein Kinases / metabolism Liver / drug effects Mice Mice, Inbred ICR Signal Transduction Transcription Factor CHOP / metabolism
Apoptosis CHOP signaling Caspase-12 signaling Copper ER stress JNK signaling Mouse

Journal

Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381

Informations de publication

Date de publication:
15 Mar 2020
Historique:
received: 13 11 2019
revised: 16 01 2020
accepted: 21 01 2020
pubmed: 1 2 2020
medline: 6 5 2020
entrez: 1 2 2020
Statut: ppublish

Résumé

Copper (Cu), a transition metal, is an essential trace element in human and animal nutrition at low concentration, but Cu has toxic effects on tissues and organs at high concentration. Endoplasmic reticulum (ER) is a toxicological target in Cu poison. Thus far, no studies have focused on the relationship among copper, endoplasmic reticulum (ER) stress and apoptosis in animal and human livers. In the present study, mice treated with copper sulfate (CuSO

Identifiants

DOI: 10.1016/j.ecoenv.2020.110236 PMID: 32001424
pubmed: 32001424
pii: S0147-6513(20)30075-0
doi: 10.1016/j.ecoenv.2020.110236
pii:
doi:

Substances chimiques

Endoplasmic Reticulum Chaperone BiP 0
HSPA5 protein, human 0
Hspa5 protein, mouse 0
Transcription Factor CHOP 147336-12-7
JNK Mitogen-Activated Protein Kinases EC 2.7.11.24
Caspase 12 EC 3.4.22.-
Copper Sulfate LRX7AJ16DT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110236

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that there are no conflicts of interest.

Auteurs

Hongbin Wu (H)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.

Hongrui Guo (H)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.

Huan Liu (H)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.

Hengmin Cui (H)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Agricultural information engineering of Sichuan Province, Sichuan Agriculture University, Yaan, Sichuan, 625014, China. Electronic address: cui580420@sicau.edu.cn.

Jing Fang (J)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.

Zhicai Zuo (Z)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.

Junliang Deng (J)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.

Yinglun Li (Y)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.

Xun Wang (X)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.

Ling Zhao (L)

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Caspases initiatrices › Caspase-12 › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfates › Sulfate de cuivre › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Protéines du choc thermique › Protéines du choc thermique HSP70 › Chaperonne BiP du réticulum endoplasmique › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Stress du réticulum endoplasmique › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › JNK Mitogen-Activated Protein Kinases › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Système digestif › Foie › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée ICR › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Copper sulfate-induced endoplasmic reticulum...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Protéines liant les séquences stimulatrices de type CCAAT › Facteur de transcription CHOP › Copper sulfate-induced endoplasmic reticulum...