Cerebrospinal fluid influx drives acute ischemic tissue swelling.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
13 03 2020
13 03 2020
Historique:
received:
22
06
2019
revised:
16
12
2019
accepted:
17
01
2020
pubmed:
1
2
2020
medline:
10
4
2020
entrez:
1
2
2020
Statut:
ppublish
Résumé
Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies.
Identifiants
pubmed: 32001524
pii: science.aax7171
doi: 10.1126/science.aax7171
pmc: PMC7375109
mid: NIHMS1599846
pii:
doi:
Substances chimiques
Aquaporin 5
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : K08 NS089830
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS097265
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG053991
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS110049
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100366
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057575
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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