Differential impact of interleukin-6 promoter gene polymorphism on hippocampal volume in antipsychotic-naïve schizophrenia patients.
Differential susceptibility
hippocampus
interleukin-6
rs18000795 polymorphism
schizophrenia
Journal
Indian journal of psychiatry
ISSN: 0019-5545
Titre abrégé: Indian J Psychiatry
Pays: India
ID NLM: 0013255
Informations de publication
Date de publication:
Historique:
received:
16
08
2019
accepted:
02
10
2019
entrez:
1
2
2020
pubmed:
1
2
2020
medline:
1
2
2020
Statut:
ppublish
Résumé
Differential susceptibility model hypothesizes that a genotype need not be unfavorable all the time as postulated in stress-diathesis model but can be beneficial in a supportive context. Single-nucleotide polymorphism (SNP) (rs18000795) within the promoter region of interleukin-6 (IL-6) gene was earlier noted to have a differential susceptibility on hippocampal volume in schizophrenia (SCZ). We examined antipsychotic-naïve/free SCZ patients ( A significantly deficient right ( A paradoxical smaller hippocampal volume with GG genotype was noted in SCZ. Further elucidation of its mechanistic basis might have translational implications.
Sections du résumé
BACKGROUND
BACKGROUND
Differential susceptibility model hypothesizes that a genotype need not be unfavorable all the time as postulated in stress-diathesis model but can be beneficial in a supportive context. Single-nucleotide polymorphism (SNP) (rs18000795) within the promoter region of interleukin-6 (IL-6) gene was earlier noted to have a differential susceptibility on hippocampal volume in schizophrenia (SCZ).
MATERIALS AND METHODS
METHODS
We examined antipsychotic-naïve/free SCZ patients (
RESULTS
RESULTS
A significantly deficient right (
CONCLUSION
CONCLUSIONS
A paradoxical smaller hippocampal volume with GG genotype was noted in SCZ. Further elucidation of its mechanistic basis might have translational implications.
Identifiants
pubmed: 32001929
doi: 10.4103/psychiatry.IndianJPsychiatry_486_19
pii: IJPsy-62-36
pmc: PMC6964441
doi:
Types de publication
Journal Article
Langues
eng
Pagination
36-42Informations de copyright
Copyright: © 2020 Indian Journal of Psychiatry.
Déclaration de conflit d'intérêts
There are no conflicts of interest
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