Monocytes mediate homing of circulating microvesicles to the pulmonary vasculature during low-grade systemic inflammation.
Extracellular vesicles
microvesicles
monocytes
pulmonary vasculature
systemic inflammation
Journal
Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
06
2019
revised:
07
12
2019
accepted:
13
12
2019
entrez:
1
2
2020
pubmed:
1
2
2020
medline:
1
2
2020
Statut:
epublish
Résumé
Microvesicles (MVs), a plasma membrane-derived subclass of extracellular vesicles, are produced and released into the circulation during systemic inflammation, yet little is known of cell/tissue-specific uptake of MVs under these conditions. We hypothesized that monocytes contribute to uptake of circulating MVs and that their increased margination to the pulmonary circulation and functional priming during systemic inflammation produces substantive changes to the systemic MV homing profile. Cellular uptake of i.v.-injected, fluorescently labelled MVs (J774.1 macrophage-derived) in vivo was quantified by flow cytometry in vascular cell populations of the lungs, liver and spleen of C57BL6 mice. Under normal conditions, both Ly6C
Identifiants
pubmed: 32002170
doi: 10.1080/20013078.2019.1706708
pii: 1706708
pmc: PMC6968433
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1706708Subventions
Organisme : Medical Research Council
ID : MR/M018164/1
Pays : United Kingdom
Informations de copyright
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.
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