DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes.
Animals
Arabidopsis
/ chemistry
Arabidopsis Proteins
/ chemistry
Axin Protein
/ chemistry
Bryopsida
/ chemistry
COS Cells
Cell Polarity
/ physiology
Chlorocebus aethiops
Dishevelled Proteins
/ metabolism
HEK293 Cells
Humans
Marchantia
/ chemistry
Membrane Proteins
/ chemistry
Plant Cells
/ physiology
Plants, Genetically Modified
Polymerization
Protein Domains
Repressor Proteins
/ metabolism
Wnt Signaling Pathway
DIX domain
SOSEKI
cell polarity
dishevelled
plant development
protein oligomerization
signalosome
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
06 02 2020
06 02 2020
Historique:
received:
27
05
2019
revised:
18
10
2019
accepted:
06
01
2020
pubmed:
1
2
2020
medline:
22
8
2020
entrez:
1
2
2020
Statut:
ppublish
Résumé
Cell polarity is fundamental for tissue morphogenesis in multicellular organisms. Plants and animals evolved multicellularity independently, and it is unknown whether their polarity systems are derived from a single-celled ancestor. Planar polarity in animals is conferred by Wnt signaling, an ancient signaling pathway transduced by Dishevelled, which assembles signalosomes by dynamic head-to-tail DIX domain polymerization. In contrast, polarity-determining pathways in plants are elusive. We recently discovered Arabidopsis SOSEKI proteins, which exhibit polar localization throughout development. Here, we identify SOSEKI as ancient polar proteins across land plants. Concentration-dependent polymerization via a bona fide DIX domain allows these to recruit ANGUSTIFOLIA to polar sites, similar to the polymerization-dependent recruitment of signaling effectors by Dishevelled. Cross-kingdom domain swaps reveal functional equivalence of animal and plant DIX domains. We trace DIX domains to unicellular eukaryotes and thus show that DIX-dependent polymerization is an ancient mechanism conserved between kingdoms and central to polarity proteins.
Identifiants
pubmed: 32004461
pii: S0092-8674(20)30058-1
doi: 10.1016/j.cell.2020.01.011
pmc: PMC7042713
pii:
doi:
Substances chimiques
ANGUSTIFOLIA protein, Arabidopsis
0
AT3G46110 protein, Arabidopsis
0
Arabidopsis Proteins
0
Axin Protein
0
Dishevelled Proteins
0
Membrane Proteins
0
Repressor Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
427-439.e12Subventions
Organisme : Medical Research Council
ID : MC_U105192713
Pays : United Kingdom
Organisme : Medical Research Council
ID : U105192713
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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