Protective effect of sodium propionate in Aβ

Amyloid beta-Peptides / toxicity Animals Cell Line, Tumor Dose-Response Relationship, Drug Humans Male Mice Neuroprotective Agents / therapeutic use Peptide Fragments / toxicity Propionates / therapeutic use Random Allocation Spinal Cord Injuries / chemically induced
Cytokines NF-κB Neuroinflammation Neuroprotection Short chain fatty acids Sodium propionate

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
04 2020
Historique:
received: 02 08 2019
revised: 13 01 2020
accepted: 23 01 2020
pubmed: 1 2 2020
medline: 7 4 2021
entrez: 1 2 2020
Statut: ppublish

Résumé

Sodium propionate (SP) is one of the main short chain fatty acids (SCFA) that can be produced naturally through host metabolic pathways. SP have been documented and include the reduction of pro-inflammatory mediators in an in vivo model of colitis. The aim of this study is to evaluate the neuroprotective effects of SP in reducing inflammatory process associated to neurological disorders. We performed both in vitro model of Alzheimer's disease, induced by oligomeric Aβ

Identifiants

DOI: 10.1016/j.neuropharm.2020.107977 PMID: 32004548
pubmed: 32004548
pii: S0028-3908(20)30043-5
doi: 10.1016/j.neuropharm.2020.107977
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Neuroprotective Agents 0
Peptide Fragments 0
Propionates 0
amyloid beta-protein (1-42) 0
sodium propionate DK6Y9P42IN

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

107977

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

A Filippone (A)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D ׳Alcontres, 31, 98166, Messina, Italy. Electronic address: afilippone@unime.it.

M Lanza (M)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D ׳Alcontres, 31, 98166, Messina, Italy. Electronic address: mlanza@unime.it.

M Campolo (M)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D ׳Alcontres, 31, 98166, Messina, Italy. Electronic address: mcampolo@unime.it.

G Casili (G)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D ׳Alcontres, 31, 98166, Messina, Italy. Electronic address: gcasili@unime.it.

I Paterniti (I)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D ׳Alcontres, 31, 98166, Messina, Italy. Electronic address: ipaterniti@unime.it.

S Cuzzocrea (S)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D ׳Alcontres, 31, 98166, Messina, Italy; Department of Pharmacological and Physiological Science, Saint Louis University, USA. Electronic address: salvator@unime.it.

E Esposito (E)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D ׳Alcontres, 31, 98166, Messina, Italy. Electronic address: eesposito@unime.it.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Eucaryotes › Animaux › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Propionates › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Répartition aléatoire › Protective effect of sodium propionate in Aβ
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › Protective effect of sodium propionate in Aβ