Structural insights into the gating mechanisms of TRPV channels.
Cryo-EM
Ion channels
TRP channels
TRPV
X-ray crystallography
Journal
Cell calcium
ISSN: 1532-1991
Titre abrégé: Cell Calcium
Pays: Netherlands
ID NLM: 8006226
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
26
11
2019
revised:
22
01
2020
accepted:
22
01
2020
pubmed:
1
2
2020
medline:
2
6
2021
entrez:
1
2
2020
Statut:
ppublish
Résumé
Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a group of cation channels modulated by a variety of endogenous stimuli as well as a range of natural and synthetic compounds. Their roles in human health make them of keen interest, particularly from a pharmacological perspective. However, despite this interest, the complexity of these channels has made it difficult to obtain high resolution structures until recently. With the cryo-EM resolution revolution, TRPV channel structural biology has blossomed to produce dozens of structures, covering every TRPV family member and a variety of approaches to examining channel modulation. Here, we review all currently available TRPV structures and the mechanistic insights into gating that they reveal.
Identifiants
pubmed: 32004816
pii: S0143-4160(20)30010-5
doi: 10.1016/j.ceca.2020.102168
pmc: PMC7153993
mid: NIHMS1555473
pii:
doi:
Substances chimiques
Transient Receptor Potential Channels
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102168Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM103899
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM129357
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM132039
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
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