Association of reduced inner retinal thicknesses with chronic kidney disease.
Aged
Biomarkers
Choroid
/ diagnostic imaging
Female
Glomerular Filtration Rate
Humans
Kidney Failure, Chronic
/ physiopathology
Male
Microvessels
/ diagnostic imaging
Middle Aged
Ophthalmoscopy
Organ Size
Photography
Renal Insufficiency, Chronic
/ physiopathology
Retina
/ diagnostic imaging
Retinal Vessels
/ diagnostic imaging
Tomography, Optical Coherence
Choroid
Choroidal vascularity index
Choroidal volume
Chronic kidney disease
Renal function
Retina
Retinal microvasculature
Retinal thickness
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
31 01 2020
31 01 2020
Historique:
received:
03
09
2019
accepted:
30
12
2019
entrez:
2
2
2020
pubmed:
2
2
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal measures, and renal function in a population with a high burden of comorbidity. Participants were recruited from nuclear cardiology or renal medicine clinics. Retinal and choroidal thickness were measured from spectral-domain optical coherence tomograms. Retinal microvascular parameters were assessed from digital fundus photographs using a semi-automated software package. Chronic kidney disease (CKD) categorised as: CKD stages 1-2, eGFR ≥60 ml/min/1.73m Participants (n = 241) had a mean age of 65 years and a mean eGFR of 66.9 ml/min/1.73m Inner retinal thinning and retinal microvascular variation is associated with advanced CKD (stages 4 & 5) independent of important confounding factors, but not with earlier stage CKD (stage 3) and, therefore, its utility as a biomarker for early CKD is not supported in this study.
Sections du résumé
BACKGROUND
Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal measures, and renal function in a population with a high burden of comorbidity.
METHODS
Participants were recruited from nuclear cardiology or renal medicine clinics. Retinal and choroidal thickness were measured from spectral-domain optical coherence tomograms. Retinal microvascular parameters were assessed from digital fundus photographs using a semi-automated software package.
MAIN OUTCOME MEASURE
Chronic kidney disease (CKD) categorised as: CKD stages 1-2, eGFR ≥60 ml/min/1.73m
RESULTS
Participants (n = 241) had a mean age of 65 years and a mean eGFR of 66.9 ml/min/1.73m
CONCLUSIONS
Inner retinal thinning and retinal microvascular variation is associated with advanced CKD (stages 4 & 5) independent of important confounding factors, but not with earlier stage CKD (stage 3) and, therefore, its utility as a biomarker for early CKD is not supported in this study.
Identifiants
pubmed: 32005180
doi: 10.1186/s12882-019-1679-1
pii: 10.1186/s12882-019-1679-1
pmc: PMC6995224
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
37Subventions
Organisme : Medical Research Council
ID : MC_PC_15025
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15027
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K003364/1
Pays : United Kingdom
Organisme : Northern Ireland Health and Social Care Research and Development Office
ID : STL/4936/14
Pays : International
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